Point-of-care diagnosis of respiratory syncytial virus by digital nanobubble detection

Yaning Liu, Haihang Ye, Ruth Levitz, Hoang Dinh Huynh, Jeff Kahn, Zhenpeng Qin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Respiratory syncytial virus (RSV) is among the leading causes of pediatric death and to date there is no effective treatment. Current diagnostic methods for RSV including polymerase chain reaction (PCR) or lateral flow immunoassay, are either costly and time consuming or lack of sufficient sensitivity. We report a novel digital nanobubble detection as a read-out method that remarkably improves the limit of detection (LOD) of the colorimetric plasmonic coupling assay (PCA) by 3 orders of magnitude. The sample-to-answer diagnosis can be achieved within 30 minutes by minimal additional time to the already rapid PCA.

Original languageEnglish (US)
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages929-930
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: Oct 27 2019Oct 31 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period10/27/1910/31/19

Keywords

  • Digital nanobubble detection
  • Microfluidics
  • Plasmonic coupling assay
  • Plasmonic nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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