Poising chromatin for transcription

David S. Gross; William T. Garrard

doi:10.1016/0968-0004(87)90144-7

Poising chromatin for transcription

David S. Gross, William T. Garrard

Molecular Biology

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.

Original language	English (US)
Pages (from-to)	293-297
Number of pages	5
Journal	Trends in biochemical sciences
Volume	12
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(87)90144-7
State	Published - 1987

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1016/0968-0004(87)90144-7

Cite this

@article{419ba55bed44420da5d14e73c470653b,

title = "Poising chromatin for transcription",

abstract = "Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.",

author = "Gross, {David S.} and Garrard, {William T.}",

note = "Funding Information: Acknowledgements We wish to thank C Szent-Gyorgyt and V Blasquez for review and M Rotond~ and C A Ardom for assistance m prepanng this manuscript Work performed m the laboratory of W T Garrard was supported by grants GM22201, GM29935 and GM31689 from the Nauonal InstRutes of Health and grant 1-823 from The Robert A Welch Foundation",

year = "1987",

doi = "10.1016/0968-0004(87)90144-7",

language = "English (US)",

volume = "12",

pages = "293--297",

journal = "Trends in biochemical sciences",

issn = "0968-0004",

publisher = "Elsevier Limited",

number = "C",

}

TY - JOUR

T1 - Poising chromatin for transcription

AU - Gross, David S.

AU - Garrard, William T.

N1 - Funding Information: Acknowledgements We wish to thank C Szent-Gyorgyt and V Blasquez for review and M Rotond~ and C A Ardom for assistance m prepanng this manuscript Work performed m the laboratory of W T Garrard was supported by grants GM22201, GM29935 and GM31689 from the Nauonal InstRutes of Health and grant 1-823 from The Robert A Welch Foundation

PY - 1987

Y1 - 1987

N2 - Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.

AB - Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.

UR - http://www.scopus.com/inward/record.url?scp=0000742962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000742962&partnerID=8YFLogxK

U2 - 10.1016/0968-0004(87)90144-7

DO - 10.1016/0968-0004(87)90144-7

M3 - Article

AN - SCOPUS:0000742962

SN - 0968-0004

VL - 12

SP - 293

EP - 297

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - C

ER -

Poising chromatin for transcription

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this