Poising chromatin for transcription

David S. Gross, William T. Garrard

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalTrends in Biochemical Sciences
Volume12
Issue numberC
DOIs
StatePublished - 1987

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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