Poising chromatin for transcription

David S. Gross, William T. Garrard

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Interactions between cis-acting DNA sequences and trans-acting factors regulate gene expression in eukaryotic cells. In chromatin, these protein-DNA complexes frequently generate DNase I hypersensitive sites, are sometimes organized at or near the bases of chromosomal loops, and can instruct an entire linked domain to memorize the transcriptionally poised state.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalTrends in biochemical sciences
Issue numberC
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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