Poly(ADP-ribose) polymerase 1 is a key regulator of estrogen receptor α-dependent gene transcription

Fengxiao Zhang, Yan Wang, Lin Wang, Xi Luo, Kun Huang, Cheng Wang, Meng Du, Fangmei Liu, Ting Luo, Dan Huang, Kai Huang

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Background: Poly(ADP-ribose) polymerase 1 (PARP1) exerts important functions in transcriptional regulation of transcription factors. Results: PAPR1 interacts with estrogen receptor α (ERα), and poly(ADP-ribosyl) ation promotes ERα transactivation. Conclusion: PARP1 is a crucial regulator of ERα-dependent gene transcription. Significance: This might be the first study examining the interpaly between PARP1 and ERα, and identifies that PARP1 controls ERα transactivation.

Original languageEnglish (US)
Pages (from-to)11348-11357
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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