Polyclonal antibody-induced serum sickness in renal transplant recipients: Treatment with therapeutic plasma exchange

Bekir Tanriover; Peale Chuang; Bernard Fishbach; J. Harold Helderman; Tarik Kizilisik; William Nylander; David Shaffer; Anthony J. Langone

doi:10.1097/01.TP.0000165093.13046.B3

Polyclonal antibody-induced serum sickness in renal transplant recipients: Treatment with therapeutic plasma exchange

Bekir Tanriover, Peale Chuang, Bernard Fishbach, J. Harold Helderman, Tarik Kizilisik, William Nylander, David Shaffer, Anthony J. Langone

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Serum sickness is an immune-complex mediated illness that frequently occurs in patients after polyclonal antibody therapy (ATGAM or thymoglobulin). Serum sickness presents with significant morbidity but is self-limited and resolves with prolonged steroid therapy. We present five renal transplant patients who developed serum sickness after polyclonal antibody treatment with severe symptoms that persisted after being started on systemic steroids. These patients underwent one or two courses of therapeutic plasma exchange (TPE) with subsequent complete resolution of their symptoms. Renal transplant recipients with serum sickness after polyclonal antibody therapy may benefit from TPE by accelerating their time to recovery and thereby reducing overall morbidity.

Original language	English (US)
Pages (from-to)	279-281
Number of pages	3
Journal	Transplantation
Volume	80
Issue number	2
DOIs	https://doi.org/10.1097/01.TP.0000165093.13046.B3
State	Published - Jul 27 2005

ASJC Scopus subject areas

Transplantation

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abstract = "Serum sickness is an immune-complex mediated illness that frequently occurs in patients after polyclonal antibody therapy (ATGAM or thymoglobulin). Serum sickness presents with significant morbidity but is self-limited and resolves with prolonged steroid therapy. We present five renal transplant patients who developed serum sickness after polyclonal antibody treatment with severe symptoms that persisted after being started on systemic steroids. These patients underwent one or two courses of therapeutic plasma exchange (TPE) with subsequent complete resolution of their symptoms. Renal transplant recipients with serum sickness after polyclonal antibody therapy may benefit from TPE by accelerating their time to recovery and thereby reducing overall morbidity.",

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AU - Tanriover, Bekir

AU - Chuang, Peale

AU - Fishbach, Bernard

AU - Helderman, J. Harold

AU - Kizilisik, Tarik

AU - Nylander, William

AU - Shaffer, David

AU - Langone, Anthony J.

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AB - Serum sickness is an immune-complex mediated illness that frequently occurs in patients after polyclonal antibody therapy (ATGAM or thymoglobulin). Serum sickness presents with significant morbidity but is self-limited and resolves with prolonged steroid therapy. We present five renal transplant patients who developed serum sickness after polyclonal antibody treatment with severe symptoms that persisted after being started on systemic steroids. These patients underwent one or two courses of therapeutic plasma exchange (TPE) with subsequent complete resolution of their symptoms. Renal transplant recipients with serum sickness after polyclonal antibody therapy may benefit from TPE by accelerating their time to recovery and thereby reducing overall morbidity.

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Polyclonal antibody-induced serum sickness in renal transplant recipients: Treatment with therapeutic plasma exchange

Abstract

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