TY - JOUR
T1 - Polycythemia associated with primary systemic amyloidosis
T2 - Elevated levels of hemopoietic factors and cytokines
AU - Nagasawa, T.
AU - Yanagisawa, H.
AU - Hasegawa, Y.
AU - Kanma, H.
AU - Abe, T.
PY - 1993/5
Y1 - 1993/5
N2 - A 60‐year‐old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/μl, and platelets 60.5 × 104/μl). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony‐forming units (CFU)‐G, CFU‐GM, CFU‐E, and CFU‐Meg. Serum levels of erythropoietin (Epo), granulocyte colony‐stimulating factor (G‐CSF), interleukin (IL)‐3 and IL‐6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor‐producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.
AB - A 60‐year‐old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/μl, and platelets 60.5 × 104/μl). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony‐forming units (CFU)‐G, CFU‐GM, CFU‐E, and CFU‐Meg. Serum levels of erythropoietin (Epo), granulocyte colony‐stimulating factor (G‐CSF), interleukin (IL)‐3 and IL‐6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor‐producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.
KW - PSA
KW - amyloid fibrils
KW - hemopoietic stem cell
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U2 - 10.1002/ajh.2830430114
DO - 10.1002/ajh.2830430114
M3 - Article
C2 - 8317465
AN - SCOPUS:0027322219
SN - 0361-8609
VL - 43
SP - 57
EP - 60
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -