Polycythemia associated with primary systemic amyloidosis: Elevated levels of hemopoietic factors and cytokines

T. Nagasawa, H. Yanagisawa, Y. Hasegawa, H. Kanma, T. Abe

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A 60‐year‐old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/μl, and platelets 60.5 × 104/μl). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony‐forming units (CFU)‐G, CFU‐GM, CFU‐E, and CFU‐Meg. Serum levels of erythropoietin (Epo), granulocyte colony‐stimulating factor (G‐CSF), interleukin (IL)‐3 and IL‐6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor‐producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalAmerican Journal of Hematology
Volume43
Issue number1
DOIs
StatePublished - May 1993

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Keywords

  • PSA
  • amyloid fibrils
  • hemopoietic stem cell

ASJC Scopus subject areas

  • Hematology

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