Polycythemia associated with primary systemic amyloidosis

Elevated levels of hemopoietic factors and cytokines

T. Nagasawa, H. Yanagisawa, Y. Hasegawa, H. Kanma, T. Abe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 60-year-old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/μl, and platelets 60.5 x 104/μl). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony-forming units (CFU)-G, CFU-GM, CFU-E, and CFU-Meg. Serum levels of erythropoietin (Epo), granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-3 and IL-6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor-producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalAmerican Journal of Hematology
Volume43
Issue number1
StatePublished - 1993

Fingerprint

Polycythemia
Stem Cells
Cytokines
Colony-Forming Units Assay
Interleukin-3
Thromboplastin
Granulocyte Colony-Stimulating Factor
Erythropoietin
Amyloid
Interleukin-6
Blood Platelets
Primary amyloidosis
Serum

Keywords

  • amyloid fibrils
  • hemopoietic
  • PSA
  • stem cell

ASJC Scopus subject areas

  • Hematology

Cite this

Polycythemia associated with primary systemic amyloidosis : Elevated levels of hemopoietic factors and cytokines. / Nagasawa, T.; Yanagisawa, H.; Hasegawa, Y.; Kanma, H.; Abe, T.

In: American Journal of Hematology, Vol. 43, No. 1, 1993, p. 57-60.

Research output: Contribution to journalArticle

Nagasawa, T, Yanagisawa, H, Hasegawa, Y, Kanma, H & Abe, T 1993, 'Polycythemia associated with primary systemic amyloidosis: Elevated levels of hemopoietic factors and cytokines', American Journal of Hematology, vol. 43, no. 1, pp. 57-60.
Nagasawa, T. ; Yanagisawa, H. ; Hasegawa, Y. ; Kanma, H. ; Abe, T. / Polycythemia associated with primary systemic amyloidosis : Elevated levels of hemopoietic factors and cytokines. In: American Journal of Hematology. 1993 ; Vol. 43, No. 1. pp. 57-60.
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