Polyfluoroalkyl compounds in Texas children from birth through 12 years of age

Arnold Schecter, Noor Malik-Bass, Antonia M. Calafat, Kayoko Kato, Justin A. Colacino, Tyra L. Gent, Linda S. Hynan, T. Robert Harris, Sunitha Malla, Linda Birnbaum

Research output: Contribution to journalArticle

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Abstract

Background: For > 50 years, polyfluoroalkyl compounds (PFCs) have been used worldwide, mainly as surfactants and emulsifiers, and human exposure to some PFCs is widespread. Objectives: Our goal was to report PFC serum concentrations from a convenience sample of Dallas, Texas, children from birth to < 13 years of age, and to examine age and sex differences in PFC concentrations. Methods: We analyzed 300 serum samples collected in 2009 for eight PFCs by online solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry. Results: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in > 92% of participants; the other PFCs measured were detected less frequently. Overall median concentrations of PFOS (4.1 ng/mL) were higher than those for PFOA (2.85 ng/mL), PFNA (1.2 ng/mL), and PFHxS (1.2 ng/mL). For PFOS, PFOA, PFNA, and PFHxS, we found no significant differences (p < 0.05) by sex, significantly increasing concentrations for all four chemicals by age, and significantly positive correlations between all four compounds. Conclusions: We found no significant differences in the serum concentrations of PFOS, PFOA, PFNA, and PFHxS by sex, but increasing concentrations with age. Our results suggest that these 300 Texas children from birth through 12 years of age continued to be exposed to several PFCs in late 2009, years after changes in production of some PFCs in the United States.

Original languageEnglish (US)
Pages (from-to)590-594
Number of pages5
JournalEnvironmental Health Perspectives
Volume120
Issue number4
DOIs
StatePublished - Apr 2012

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Parturition
Serum
Surface-Active Agents

Keywords

  • Blood
  • Children
  • Infants
  • PFC
  • PFOA
  • PFOS
  • Polyfluoroalkyl compounds
  • United States

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Schecter, A., Malik-Bass, N., Calafat, A. M., Kato, K., Colacino, J. A., Gent, T. L., ... Birnbaum, L. (2012). Polyfluoroalkyl compounds in Texas children from birth through 12 years of age. Environmental Health Perspectives, 120(4), 590-594. https://doi.org/10.1289/ehp.1104325

Polyfluoroalkyl compounds in Texas children from birth through 12 years of age. / Schecter, Arnold; Malik-Bass, Noor; Calafat, Antonia M.; Kato, Kayoko; Colacino, Justin A.; Gent, Tyra L.; Hynan, Linda S.; Robert Harris, T.; Malla, Sunitha; Birnbaum, Linda.

In: Environmental Health Perspectives, Vol. 120, No. 4, 04.2012, p. 590-594.

Research output: Contribution to journalArticle

Schecter, A, Malik-Bass, N, Calafat, AM, Kato, K, Colacino, JA, Gent, TL, Hynan, LS, Robert Harris, T, Malla, S & Birnbaum, L 2012, 'Polyfluoroalkyl compounds in Texas children from birth through 12 years of age', Environmental Health Perspectives, vol. 120, no. 4, pp. 590-594. https://doi.org/10.1289/ehp.1104325
Schecter A, Malik-Bass N, Calafat AM, Kato K, Colacino JA, Gent TL et al. Polyfluoroalkyl compounds in Texas children from birth through 12 years of age. Environmental Health Perspectives. 2012 Apr;120(4):590-594. https://doi.org/10.1289/ehp.1104325
Schecter, Arnold ; Malik-Bass, Noor ; Calafat, Antonia M. ; Kato, Kayoko ; Colacino, Justin A. ; Gent, Tyra L. ; Hynan, Linda S. ; Robert Harris, T. ; Malla, Sunitha ; Birnbaum, Linda. / Polyfluoroalkyl compounds in Texas children from birth through 12 years of age. In: Environmental Health Perspectives. 2012 ; Vol. 120, No. 4. pp. 590-594.
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abstract = "Background: For > 50 years, polyfluoroalkyl compounds (PFCs) have been used worldwide, mainly as surfactants and emulsifiers, and human exposure to some PFCs is widespread. Objectives: Our goal was to report PFC serum concentrations from a convenience sample of Dallas, Texas, children from birth to < 13 years of age, and to examine age and sex differences in PFC concentrations. Methods: We analyzed 300 serum samples collected in 2009 for eight PFCs by online solid phase extraction-high performance liquid chromatography-isotope dilution-tandem mass spectrometry. Results: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in > 92{\%} of participants; the other PFCs measured were detected less frequently. Overall median concentrations of PFOS (4.1 ng/mL) were higher than those for PFOA (2.85 ng/mL), PFNA (1.2 ng/mL), and PFHxS (1.2 ng/mL). For PFOS, PFOA, PFNA, and PFHxS, we found no significant differences (p < 0.05) by sex, significantly increasing concentrations for all four chemicals by age, and significantly positive correlations between all four compounds. Conclusions: We found no significant differences in the serum concentrations of PFOS, PFOA, PFNA, and PFHxS by sex, but increasing concentrations with age. Our results suggest that these 300 Texas children from birth through 12 years of age continued to be exposed to several PFCs in late 2009, years after changes in production of some PFCs in the United States.",
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AU - Gent, Tyra L.

AU - Hynan, Linda S.

AU - Robert Harris, T.

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