Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(II)

potassium-insensitive triplex formation.

A. Ferdous, H. Watanabe, A. Maruyama, T. Akaike

Research output: Contribution to journalArticle

Abstract

Triple helix formation involving guanine-rich oligonucleotides is inhibited by physiological concentrations of potassium (K+). Using in vitro electrophoretic mobility shift assay (EMSA), we show that PLL-g-dex copolymer significantly stabilizes triplex structure at physiological levels of K+ that greatly inhibited triplex formation with a unmodified, guanine-rich oligonucleotide.

Original languageEnglish (US)
Pages (from-to)301-302
Number of pages2
JournalNucleic acids symposium series
Issue number37
StatePublished - 1997

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Guanine
Oligonucleotides
Potassium
Electrophoretic Mobility Shift Assay
triplex DNA
poly(lysine)-graft-dextran
In Vitro Techniques

Cite this

Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(II) : potassium-insensitive triplex formation. / Ferdous, A.; Watanabe, H.; Maruyama, A.; Akaike, T.

In: Nucleic acids symposium series, No. 37, 1997, p. 301-302.

Research output: Contribution to journalArticle

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