Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(II): potassium-insensitive triplex formation.

A. Ferdous, H. Watanabe, A. Maruyama, T. Akaike

Research output: Contribution to journalArticle

Abstract

Triple helix formation involving guanine-rich oligonucleotides is inhibited by physiological concentrations of potassium (K+). Using in vitro electrophoretic mobility shift assay (EMSA), we show that PLL-g-dex copolymer significantly stabilizes triplex structure at physiological levels of K+ that greatly inhibited triplex formation with a unmodified, guanine-rich oligonucleotide.

Original languageEnglish (US)
Pages (from-to)301-302
Number of pages2
JournalNucleic acids symposium series
Issue number37
StatePublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

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