Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH: Thermodynamic and kinetic studies

H. Torigoe, A. Ferdous, H. Watanabe, T. Akaike, A. Maruyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The binding constant of a homopyrimidine oligonucleotide with its target duplex for the pyrimidine-motif triplex formation at neutral pH was analyzed and found to be remarkably higher in the presence of the poly (L-lysine)- graft-dextran copolymer than that without any triplex stabilizer or in the presence of spermine. The promoting effect mainly results from the considerable increase in the association rate constant.

Original languageEnglish (US)
Pages (from-to)1655-1656
Number of pages2
JournalNucleosides and Nucleotides
Volume18
Issue number6-7
StatePublished - 1999

Fingerprint

Spermine
Thermodynamics
Oligonucleotides
Rate constants
Association reactions
Kinetics
poly(lysine)-graft-dextran
pyrimidine

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Poly(L-lysine)-graft-dextran copolymer remarkably promotes pyrimidine- motif triplex formation at neutral pH : Thermodynamic and kinetic studies. / Torigoe, H.; Ferdous, A.; Watanabe, H.; Akaike, T.; Maruyama, A.

In: Nucleosides and Nucleotides, Vol. 18, No. 6-7, 1999, p. 1655-1656.

Research output: Contribution to journalArticle

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