Polymer-stabilized perfluorobutane nanodroplets for ultrasound imaging agents

Yuran Huang, Alexander M. Vezeridis, James Wang, Zhao Wang, Matthew Thompson, Robert F. Mattrey, Nathan C. Gianneschi

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene crosslinking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number1
DOIs
StatePublished - Jan 11 2017

    Fingerprint

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this