Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Lyndsay M. Randolph; Clare L.M. Leguyader; Michael E. Hahn; Christopher M. Andolina; Joseph P. Patterson; Robert F. Mattrey; Jill E. Millstone; Mauro Botta; Miriam Scadeng; Nathan C. Gianneschi

doi:10.1039/c6sc00342g

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Lyndsay M. Randolph, Clare L.M. Leguyader, Michael E. Hahn, Christopher M. Andolina, Joseph P. Patterson, Robert F. Mattrey, Jill E. Millstone, Mauro Botta, Miriam Scadeng, Nathan C. Gianneschi

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A Gd³⁺-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

Original language	English (US)
Pages (from-to)	4230-4236
Number of pages	7
Journal	Chemical Science
Volume	7
Issue number	7
DOIs	https://doi.org/10.1039/c6sc00342g
State	Published - 2016

ASJC Scopus subject areas

General Chemistry

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title = "Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents",

abstract = "A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.",

author = "Randolph, {Lyndsay M.} and Leguyader, {Clare L.M.} and Hahn, {Michael E.} and Andolina, {Christopher M.} and Patterson, {Joseph P.} and Mattrey, {Robert F.} and Millstone, {Jill E.} and Mauro Botta and Miriam Scadeng and Gianneschi, {Nathan C.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6sc00342g",

language = "English (US)",

volume = "7",

pages = "4230--4236",

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T1 - Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

AU - Randolph, Lyndsay M.

AU - Leguyader, Clare L.M.

AU - Hahn, Michael E.

AU - Andolina, Christopher M.

AU - Patterson, Joseph P.

AU - Mattrey, Robert F.

AU - Millstone, Jill E.

AU - Botta, Mauro

AU - Scadeng, Miriam

AU - Gianneschi, Nathan C.

PY - 2016

Y1 - 2016

N2 - A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

AB - A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

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Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Abstract

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