Polymeric nanomedicine for cancer MR imaging and drug delivery

Chalermchai Khemtong, Chase W. Kessinger, Jinming Gao

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Multifunctional nanomedicine is emerging as a highly integrated platform that allows for molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of cancer. Advances in polymer and materials science are critical for the successful development of these multi-component nanocomposites in one particulate system with such a small size confinement (<200 nm). Currently, several nanoscopic therapeutic and diagnostic systems have been translated into clinical practice. In this feature article, we will provide an up-to-date review on the development and biomedical applications of nanocomposite materials for cancer diagnosis and therapy. An overview of each functional component, i.e. polymer carriers, MR imaging agents, and therapeutic drugs, will be presented. Integration of different functional components will be illustrated in several highlighted examples to demonstrate the synergy of the multifunctional nanomedicine design.

Original languageEnglish (US)
Pages (from-to)3497-3510
Number of pages14
JournalChemical Communications
Issue number24
DOIs
StatePublished - 2009

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Medical nanotechnology
Drug delivery
Nanocomposites
Polymers
Imaging techniques
Materials science
Monitoring
Pharmaceutical Preparations
Targeted drug delivery

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Polymeric nanomedicine for cancer MR imaging and drug delivery. / Khemtong, Chalermchai; Kessinger, Chase W.; Gao, Jinming.

In: Chemical Communications, No. 24, 2009, p. 3497-3510.

Research output: Contribution to journalArticle

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