TY - JOUR
T1 - Polymeric nanoparticles for drug delivery to the central nervous system
AU - Patel, Toral
AU - Zhou, Jiangbing
AU - Piepmeier, Joseph M.
AU - Saltzman, W. Mark
PY - 2012/5/15
Y1 - 2012/5/15
N2 - The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40. years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.
AB - The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40. years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.
KW - Blood-brain barrier
KW - Brain
KW - Convection-enhanced delivery
KW - Nanoparticle
KW - Polymer
UR - http://www.scopus.com/inward/record.url?scp=84860011902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860011902&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2011.12.006
DO - 10.1016/j.addr.2011.12.006
M3 - Review article
C2 - 22210134
AN - SCOPUS:84860011902
SN - 0169-409X
VL - 64
SP - 701
EP - 705
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 7
ER -