Polymeric PARACEST agents for enhancing MRI contrast sensitivity

Yunkou Wu, Youfu Zhou, Olivier Ouari, Mark Woods, Piyu Zhao, Todd C. Soesbe, Garry E. Kiefer, A. Dean Sherry

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

Original languageEnglish (US)
Pages (from-to)13854-13855
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number42
DOIs
StatePublished - Oct 22 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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