Polymeric PARACEST agents for enhancing MRI contrast sensitivity

Yunkou Wu, Youfu Zhou, Olivier Ouari, Mark Woods, Piyu Zhao, Todd C. Soesbe, Garry E. Kiefer, A. Dean Sherry

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

Original languageEnglish (US)
Pages (from-to)13854-13855
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number42
DOIs
StatePublished - Oct 22 2008

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Contrast Sensitivity
Magnetic resonance imaging
Polymers
Molecular imaging
Molecular Imaging
Free radicals
Polymerization
Free Radicals
Limit of Detection
Monomers
Imaging techniques
Water
Sensors

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Polymeric PARACEST agents for enhancing MRI contrast sensitivity. / Wu, Yunkou; Zhou, Youfu; Ouari, Olivier; Woods, Mark; Zhao, Piyu; Soesbe, Todd C.; Kiefer, Garry E.; Sherry, A. Dean.

In: Journal of the American Chemical Society, Vol. 130, No. 42, 22.10.2008, p. 13854-13855.

Research output: Contribution to journalArticle

Wu, Yunkou ; Zhou, Youfu ; Ouari, Olivier ; Woods, Mark ; Zhao, Piyu ; Soesbe, Todd C. ; Kiefer, Garry E. ; Sherry, A. Dean. / Polymeric PARACEST agents for enhancing MRI contrast sensitivity. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 42. pp. 13854-13855.
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