TY - JOUR
T1 - Polymicrobial sepsis
T2 - An analysis of 184 cases using log linear models
AU - Mackowiak, P. A.
AU - Browne, R. H.
AU - Southern, P. M.
AU - Smith, J. W.
PY - 1980
Y1 - 1980
N2 - Polymicrobial sepsis is a common and frequently fatal clinical condition that has received relatively little attention in published reports. Retrospectively, we reviewed the case records of 184 patients with polymicrobial sepsis seen at three Dallas hospitals between 1972 and 1977. Analysis of clinical data using log linear models enabled us to identify significant positive correlations (p<0.05) between mortality resulting from polymicrobial sepsis and underlying disease category, failure to manifest fever, a pulmonary portal of entry, hypotension, and hospital-associated sepsis. No significant correlation with outcome could be demonstrated for age, hospital service, species of infecting microorganisms, number of microorganisms isolated from blood, WBC count, or antimicrobial therapy. In spite of indirect evidence for synergistic relationships between microorganisms responsible for polymicrobial sepsis in man, we could not resolve whether antimicrobial regimens that are effective against all microorganisms participating in polymicrobial infections are required to insure a favorable outcome.
AB - Polymicrobial sepsis is a common and frequently fatal clinical condition that has received relatively little attention in published reports. Retrospectively, we reviewed the case records of 184 patients with polymicrobial sepsis seen at three Dallas hospitals between 1972 and 1977. Analysis of clinical data using log linear models enabled us to identify significant positive correlations (p<0.05) between mortality resulting from polymicrobial sepsis and underlying disease category, failure to manifest fever, a pulmonary portal of entry, hypotension, and hospital-associated sepsis. No significant correlation with outcome could be demonstrated for age, hospital service, species of infecting microorganisms, number of microorganisms isolated from blood, WBC count, or antimicrobial therapy. In spite of indirect evidence for synergistic relationships between microorganisms responsible for polymicrobial sepsis in man, we could not resolve whether antimicrobial regimens that are effective against all microorganisms participating in polymicrobial infections are required to insure a favorable outcome.
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U2 - 10.1097/00000441-198009000-00002
DO - 10.1097/00000441-198009000-00002
M3 - Article
C2 - 7435520
AN - SCOPUS:0018938303
SN - 0002-9629
VL - 280
SP - 73
EP - 80
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -