Polymorphous adenocarcinoma of the salivary glands: reappraisal and update

Vincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A. Bishop, Esther Hauben, Jennifer L. Hunt, Henrik Hellquist, Simon Feys, Remco de Bree, Antti A. Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalEuropean Archives of Oto-Rhino-Laryngology
DOIs
StateAccepted/In press - May 14 2018

Fingerprint

Salivary Glands
Adenocarcinoma
Minor Salivary Glands
Adjuvant Radiotherapy
Glandular and Epithelial Neoplasms
Epidemiology
Neck
Lymph Nodes
Neoplasm Metastasis
Biopsy

Keywords

  • Cribriform adenocarcinoma of minor salivary glands
  • Pathology
  • Polymorphous adenocarcinoma
  • Polymorphous low-grade adenocarcinoma
  • Prognosis
  • Salivary glands
  • Therapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Vander Poorten, V., Triantafyllou, A., Skálová, A., Stenman, G., Bishop, J. A., Hauben, E., ... Ferlito, A. (Accepted/In press). Polymorphous adenocarcinoma of the salivary glands: reappraisal and update. European Archives of Oto-Rhino-Laryngology, 1-15. https://doi.org/10.1007/s00405-018-4985-5

Polymorphous adenocarcinoma of the salivary glands : reappraisal and update. / Vander Poorten, Vincent; Triantafyllou, Asterios; Skálová, Alena; Stenman, Göran; Bishop, Justin A.; Hauben, Esther; Hunt, Jennifer L.; Hellquist, Henrik; Feys, Simon; de Bree, Remco; Mäkitie, Antti A.; Quer, Miquel; Strojan, Primož; Guntinas-Lichius, Orlando; Rinaldo, Alessandra; Ferlito, Alfio.

In: European Archives of Oto-Rhino-Laryngology, 14.05.2018, p. 1-15.

Research output: Contribution to journalArticle

Vander Poorten, V, Triantafyllou, A, Skálová, A, Stenman, G, Bishop, JA, Hauben, E, Hunt, JL, Hellquist, H, Feys, S, de Bree, R, Mäkitie, AA, Quer, M, Strojan, P, Guntinas-Lichius, O, Rinaldo, A & Ferlito, A 2018, 'Polymorphous adenocarcinoma of the salivary glands: reappraisal and update', European Archives of Oto-Rhino-Laryngology, pp. 1-15. https://doi.org/10.1007/s00405-018-4985-5
Vander Poorten, Vincent ; Triantafyllou, Asterios ; Skálová, Alena ; Stenman, Göran ; Bishop, Justin A. ; Hauben, Esther ; Hunt, Jennifer L. ; Hellquist, Henrik ; Feys, Simon ; de Bree, Remco ; Mäkitie, Antti A. ; Quer, Miquel ; Strojan, Primož ; Guntinas-Lichius, Orlando ; Rinaldo, Alessandra ; Ferlito, Alfio. / Polymorphous adenocarcinoma of the salivary glands : reappraisal and update. In: European Archives of Oto-Rhino-Laryngology. 2018 ; pp. 1-15.
@article{c2cdfddb9b0c4e4e8b6b63459e567dd4,
title = "Polymorphous adenocarcinoma of the salivary glands: reappraisal and update",
abstract = "Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.",
keywords = "Cribriform adenocarcinoma of minor salivary glands, Pathology, Polymorphous adenocarcinoma, Polymorphous low-grade adenocarcinoma, Prognosis, Salivary glands, Therapy",
author = "{Vander Poorten}, Vincent and Asterios Triantafyllou and Alena Sk{\'a}lov{\'a} and G{\"o}ran Stenman and Bishop, {Justin A.} and Esther Hauben and Hunt, {Jennifer L.} and Henrik Hellquist and Simon Feys and {de Bree}, Remco and M{\"a}kitie, {Antti A.} and Miquel Quer and Primož Strojan and Orlando Guntinas-Lichius and Alessandra Rinaldo and Alfio Ferlito",
year = "2018",
month = "5",
day = "14",
doi = "10.1007/s00405-018-4985-5",
language = "English (US)",
pages = "1--15",
journal = "Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde",
issn = "0003-9195",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Polymorphous adenocarcinoma of the salivary glands

T2 - reappraisal and update

AU - Vander Poorten, Vincent

AU - Triantafyllou, Asterios

AU - Skálová, Alena

AU - Stenman, Göran

AU - Bishop, Justin A.

AU - Hauben, Esther

AU - Hunt, Jennifer L.

AU - Hellquist, Henrik

AU - Feys, Simon

AU - de Bree, Remco

AU - Mäkitie, Antti A.

AU - Quer, Miquel

AU - Strojan, Primož

AU - Guntinas-Lichius, Orlando

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

AB - Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.

KW - Cribriform adenocarcinoma of minor salivary glands

KW - Pathology

KW - Polymorphous adenocarcinoma

KW - Polymorphous low-grade adenocarcinoma

KW - Prognosis

KW - Salivary glands

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85046889465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046889465&partnerID=8YFLogxK

U2 - 10.1007/s00405-018-4985-5

DO - 10.1007/s00405-018-4985-5

M3 - Article

C2 - 29761209

AN - SCOPUS:85046889465

SP - 1

EP - 15

JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

SN - 0003-9195

ER -