Polysilsesquioxane nanoparticles for triggered release of cisplatin and effective cancer chemoradiotherapy

Joseph Della Rocca, Michael E. Werner, Stephanie A. Kramer, Rachel C. Huxford-Phillips, Rohit Sukumar, Natalie D. Cummings, Juan L. Vivero-Escoto, Andrew Z. Wang, Wenbin Lin

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Chemoradiotherapy is a well-established treatment paradigm in oncology. There has been strong interest in identifying strategies to further improve its therapeutic index. An innovative strategy is to utilize nanoparticle (NP) chemotherapeutics in chemoradiation. Since the most commonly utilized chemotherapeutic with radiotherapy is cisplatin, the development of an NP cisplatin for chemoradiotherapy has the highest potential impact on this treatment. Here, we report the development of an NP comprised of polysilsesquioxane (PSQ) polymer crosslinked by a cisplatin prodrug (Cisplatin-PSQ) and its utilization in chemoradiotherapy using non-small cell lung cancer as a disease model. Cisplatin-PSQ NP has an exceptionally high loading of cisplatin. Cisplatin-PSQ NPs were evaluated in chemoradiotherapy in vitro and in vivo. They demonstrated significantly higher therapeutic efficacy when compared to cisplatin. These results suggest that the Cisplatin-PSQ NP holds potential for clinical translation in chemoradiotherapy. From the Clinical Editor: These authors present an innovative strategy utilizing the presence of platinum in nanoparticle chemotherapeutics for chemoradiation, demonstrating its efficacy in a non-small cell lung cancer model.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Cancer chemoradiotherapy
  • Cisplatin
  • Hybrid nanomaterials
  • Lung cancer
  • Nanomedicine
  • Polysilsesquioxane
  • Silica

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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