Polysomnographic parameters in first-degree relatives of unipolar probands

Donna E. Giles, David J. Kupfer, Howard P. Roffwarg, A. John Rush, Melanie M. Biggs, Barbara A. Etzel

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

We present polysomnographic data for psychiatrically asymptomatic first-degree relatives of unipolar depressed probands. Relatives were classified by proband rapid eye movement (REM) latency (reduced/nonreduced) and by personal REM latency (reduced/nonreduced). Reduced REM latency relatives, whether defined by the proband or by their own REM latency, had polysomnographic alterations consistent with those found in depressed patients, although none of these relatives was depressed at assessment. Reduced REM latency relatives with a history of unipolar depression were compared to reduced REM latency relatives with no history of depression. Virtually no polysomnographic differences were found. Polysomnographic alterations may be stable antecedents of the onset of depression.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalPsychiatry research
Volume27
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • Polysomnogram
  • REM latency
  • risk factors
  • unipolar depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Giles, D. E., Kupfer, D. J., Roffwarg, H. P., Rush, A. J., Biggs, M. M., & Etzel, B. A. (1989). Polysomnographic parameters in first-degree relatives of unipolar probands. Psychiatry research, 27(2), 127-136. https://doi.org/10.1016/0165-1781(89)90128-5