Ponce de Leon's fountain: Stem cells and the regenerating heart

Daniel J. Garry, Amanda M. Masino, R. Haris Naseem, Cindy M. Martin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Despite current pharmacologic and whole organ transplantation strategies, advanced heart failure remains a common and deadly disease. Limited availability of donor organs for use in orthotopic heart transplantation has prompted the examination of alternative therapies, including cell transfer strategies. Stem cell populations have been identified in virtually all postnatal tissues with the exception of the heart, and these stem cells function in the maintenance and regeneration of the respective tissues. Recent studies challenge preexisting notions regarding cardiac repair and suggest that the heart is capable of limited regeneration through the activation of resident cardiac stem cells or the recruitment of stem cell populations from other tissues such as the bone marrow. This review highlights animal models that have the capacity for myocardial regeneration and examines potential sources of stem cell populations that may participate in tissue regeneration. While some authors view these cell-based strategies as a Fountain of Youth for the myopathic heart, future studies will decipher the regulatory mechanisms of stem cell populations and serve as a prelude to stem cell-based strategies.

Original languageEnglish (US)
Pages (from-to)190-201
Number of pages12
JournalAmerican Journal of the Medical Sciences
Volume329
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Stem Cells
Regeneration
Population
Organ Transplantation
Heart Transplantation
Complementary Therapies
Animal Models
Heart Failure
Bone Marrow
Maintenance
Tissue Donors

Keywords

  • Abcg2
  • Cardiac stem cells
  • Cell-based therapies
  • Myocardial regeneration
  • SP cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ponce de Leon's fountain : Stem cells and the regenerating heart. / Garry, Daniel J.; Masino, Amanda M.; Naseem, R. Haris; Martin, Cindy M.

In: American Journal of the Medical Sciences, Vol. 329, No. 4, 04.2005, p. 190-201.

Research output: Contribution to journalArticle

Garry, Daniel J. ; Masino, Amanda M. ; Naseem, R. Haris ; Martin, Cindy M. / Ponce de Leon's fountain : Stem cells and the regenerating heart. In: American Journal of the Medical Sciences. 2005 ; Vol. 329, No. 4. pp. 190-201.
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