Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides

Grace Sun, Cindy Berthelot, Yafang Li, Donald A. Glass, Dornechia George, Amit Pandya, Razelle Kurzrock, Madeleine Duvic

Research output: Contribution to journalArticle

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Abstract

Background: Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is most often seen in middle-aged to elderly men. Objective: We conducted a retrospective study of the demographics and prognosis of patients with onset of MF before age 40 years. Methods: Demographic data (age, sex, and race) and histology from 1074 patents with cutaneous T-cell lymphoma were stratified by age of onset and race and analyzed using Chi-square test. Results: Women presented before age 40 years more often than men (P = .038). Early onset of MF was diagnosed in 30 of 92 (32.6%) African American (AA), 31 of 87 (35.6%) Hispanic, and 103 of 809 (12.7%) Caucasian patients. MF was significantly more common in AA (P = .0008) and Hispanic (P = .0002) patients. Early-onset MF was more common among 21 of 60 AA women (35%, P = .0174) and 19 of 40 Hispanic women (47.5%, P = .0002) than among 50 of 350 Caucasian women (14.5%). Progression from initial TNM stage occurred in only 5 (10%) Caucasian, one (5%) Hispanic, and 8 (38%) AA women who presented before age 40 years. Six of 8 AA women who progressed died of their disease whereas two were long-term survivors after allogeneic transplantation. Limitations: This was a retrospective study at one cancer center. Conclusion: Although MF is considered to be a disease of middle-aged men, early-onset MF is more common among AA and Hispanic women. AA women with early onset may have a poor prognosis and should be considered for more aggressive therapy, including allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume60
Issue number2
DOIs
StatePublished - Feb 2009

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Mycosis Fungoides
African Americans
Hispanic Americans
Cutaneous T-Cell Lymphoma
Homologous Transplantation
Retrospective Studies
Demography
Patents
Chi-Square Distribution
Age of Onset
Survivors
Histology

ASJC Scopus subject areas

  • Dermatology

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Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides. / Sun, Grace; Berthelot, Cindy; Li, Yafang; Glass, Donald A.; George, Dornechia; Pandya, Amit; Kurzrock, Razelle; Duvic, Madeleine.

In: Journal of the American Academy of Dermatology, Vol. 60, No. 2, 02.2009, p. 231-235.

Research output: Contribution to journalArticle

Sun, Grace ; Berthelot, Cindy ; Li, Yafang ; Glass, Donald A. ; George, Dornechia ; Pandya, Amit ; Kurzrock, Razelle ; Duvic, Madeleine. / Poor prognosis in non-Caucasian patients with early-onset mycosis fungoides. In: Journal of the American Academy of Dermatology. 2009 ; Vol. 60, No. 2. pp. 231-235.
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abstract = "Background: Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, is most often seen in middle-aged to elderly men. Objective: We conducted a retrospective study of the demographics and prognosis of patients with onset of MF before age 40 years. Methods: Demographic data (age, sex, and race) and histology from 1074 patents with cutaneous T-cell lymphoma were stratified by age of onset and race and analyzed using Chi-square test. Results: Women presented before age 40 years more often than men (P = .038). Early onset of MF was diagnosed in 30 of 92 (32.6{\%}) African American (AA), 31 of 87 (35.6{\%}) Hispanic, and 103 of 809 (12.7{\%}) Caucasian patients. MF was significantly more common in AA (P = .0008) and Hispanic (P = .0002) patients. Early-onset MF was more common among 21 of 60 AA women (35{\%}, P = .0174) and 19 of 40 Hispanic women (47.5{\%}, P = .0002) than among 50 of 350 Caucasian women (14.5{\%}). Progression from initial TNM stage occurred in only 5 (10{\%}) Caucasian, one (5{\%}) Hispanic, and 8 (38{\%}) AA women who presented before age 40 years. Six of 8 AA women who progressed died of their disease whereas two were long-term survivors after allogeneic transplantation. Limitations: This was a retrospective study at one cancer center. Conclusion: Although MF is considered to be a disease of middle-aged men, early-onset MF is more common among AA and Hispanic women. AA women with early onset may have a poor prognosis and should be considered for more aggressive therapy, including allogeneic transplantation.",
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