POP-1 and anterior-posterior fate decisions in C. elegans embryos

Rueyling Lin, Russell J. Hill, James R. Priess

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop- 1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalCell
Volume92
Issue number2
DOIs
StatePublished - Jan 23 1998

Fingerprint

Embryonic Structures
Genes
Blastomeres
Invariance
Cells
Siblings
Wnt Signaling Pathway
Proteins
Cell Division

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

POP-1 and anterior-posterior fate decisions in C. elegans embryos. / Lin, Rueyling; Hill, Russell J.; Priess, James R.

In: Cell, Vol. 92, No. 2, 23.01.1998, p. 229-239.

Research output: Contribution to journalArticle

Lin, Rueyling ; Hill, Russell J. ; Priess, James R. / POP-1 and anterior-posterior fate decisions in C. elegans embryos. In: Cell. 1998 ; Vol. 92, No. 2. pp. 229-239.
@article{f7c1768d1b2848c48d525a28b9a0e044,
title = "POP-1 and anterior-posterior fate decisions in C. elegans embryos",
abstract = "Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop- 1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.",
author = "Rueyling Lin and Hill, {Russell J.} and Priess, {James R.}",
year = "1998",
month = "1",
day = "23",
doi = "10.1016/S0092-8674(00)80917-4",
language = "English (US)",
volume = "92",
pages = "229--239",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - POP-1 and anterior-posterior fate decisions in C. elegans embryos

AU - Lin, Rueyling

AU - Hill, Russell J.

AU - Priess, James R.

PY - 1998/1/23

Y1 - 1998/1/23

N2 - Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop- 1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.

AB - Blastomeres in C. elegans embryos execute lineage programs wherein the fate of a cell is correlated reproducibly with the division sequence by which that cell is born. We provide evidence that the pop- 1 gene functions to link anterior-posterior cell divisions with cell fate decisions. Each anterior cell resulting from an anterior-posterior division appears to have a higher level of nuclear POP-1 protein than does its posterior sister. Genes in the C. elegans Wnt pathway are required for this inequality in POP-1 levels. We show that loss of pop-1(+) activity leads to several types of anterior cells adopting the fates of their posterior sisters. These results suggest a mechanism for the invariance of blastomere lineages.

UR - http://www.scopus.com/inward/record.url?scp=0032559301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032559301&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(00)80917-4

DO - 10.1016/S0092-8674(00)80917-4

M3 - Article

C2 - 9458047

AN - SCOPUS:0032559301

VL - 92

SP - 229

EP - 239

JO - Cell

JF - Cell

SN - 0092-8674

IS - 2

ER -