TY - JOUR
T1 - Population-based case-control study of cognitive function in early Parkinson's disease (NEDICES)
AU - Benito-León, Julián
AU - Louis, Elan D.
AU - Posada, Ignacio J.
AU - Sánchez-Ferro, Álvaro
AU - Trincado, Rocío
AU - Villarejo, Alberto
AU - Mitchell, Alex J.
AU - Bermejo-Pareja, Félix
N1 - Funding Information:
The authors gratefully acknowledge the vital help of the other members of the NEDICES Study Group: C. Rodríguez, J.M. Morales, R. Gabriel, A. Portera-Sánchez, A. Berbel, A. Martínez-Salio, J. Díaz-Guzmán, J. Olazarán, J. Pardo, J. Porta-Etessam, F. Pérez del Molino, M. Alonso, C. Gómez, C. Saiz, G. Fernández, P. Rodríguez and F. Sánchez-Sánchez. Finally, we also wish to express our sincere thanks to J. de Pedro-Cuesta and J. Almazán, the municipal authorities, family doctors, nurses, and the populations of Getafe, Lista, and Arévalo county. NEDICES was supported by the Spanish Health Research Agency and the Spanish Office of Science and Technology. Dr. Benito-León is supported by NIH R01 NS039422 from the National Institutes of Health, Bethesda, Md., USA. Dr. Louis is supported by R01 NS042859 and R01 NS039422 from the National Institutes of Health, Bethesda, MD.
PY - 2011/11/15
Y1 - 2011/11/15
N2 - Background: Population-based assessments of cognitive function in patients with early Parkinson's disease (PD) are rare. We examined whether patients with early PD have cognitive deficits when compared with matched controls Methods: All participants were age 65 years or older (median = 76 years) and were enrolled in the Neurological Disorders in Central Spain (NEDICES) study in central Spain. We identified all participants with early PD (< 5 years duration) (N = 46). These were matched to 138 controls. Neuropsychological test scores were compared in PD patients vs. controls. In logistic regression models, we adjusted for the effects of confounding variables. In these models, the dependent variable was the neuropsychological test score (lowest quartile vs. all other quartiles) and the independent variable was PD vs. control. Results: Sixteen of 46 patients (34.8%) with early PD were previously undiagnosed. Subjective memory complaint was present in 27 (58.7%) PD patients vs. 51 (37.0%) controls (p = 0.010). In logistic regression models that adjusted for gender, education, and depressive symptoms or antidepressant use, PD patients performed less well on the 37-item version of the Mini-Mental State Examination (p = 0.04), animal (p < 0.001) and fruit fluency (p = 0.04) as well as in a delayed free recall memory test (p = 0.04) than controls. Conclusions: In this population-based sample of older patients with early PD, the rate of subjective and object cognitive impairment was appreciable. Patients with PD of less than five years duration performed relatively poorly on tests of global cognition, verbal fluency and memory. Clinicians should be vigilant to these cognitive difficulties even in the early stages of PD.
AB - Background: Population-based assessments of cognitive function in patients with early Parkinson's disease (PD) are rare. We examined whether patients with early PD have cognitive deficits when compared with matched controls Methods: All participants were age 65 years or older (median = 76 years) and were enrolled in the Neurological Disorders in Central Spain (NEDICES) study in central Spain. We identified all participants with early PD (< 5 years duration) (N = 46). These were matched to 138 controls. Neuropsychological test scores were compared in PD patients vs. controls. In logistic regression models, we adjusted for the effects of confounding variables. In these models, the dependent variable was the neuropsychological test score (lowest quartile vs. all other quartiles) and the independent variable was PD vs. control. Results: Sixteen of 46 patients (34.8%) with early PD were previously undiagnosed. Subjective memory complaint was present in 27 (58.7%) PD patients vs. 51 (37.0%) controls (p = 0.010). In logistic regression models that adjusted for gender, education, and depressive symptoms or antidepressant use, PD patients performed less well on the 37-item version of the Mini-Mental State Examination (p = 0.04), animal (p < 0.001) and fruit fluency (p = 0.04) as well as in a delayed free recall memory test (p = 0.04) than controls. Conclusions: In this population-based sample of older patients with early PD, the rate of subjective and object cognitive impairment was appreciable. Patients with PD of less than five years duration performed relatively poorly on tests of global cognition, verbal fluency and memory. Clinicians should be vigilant to these cognitive difficulties even in the early stages of PD.
KW - Cognitive function
KW - Elderly
KW - Epidemiology
KW - Parkinson's disease
KW - Population-based study
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U2 - 10.1016/j.jns.2011.06.054
DO - 10.1016/j.jns.2011.06.054
M3 - Article
C2 - 21774946
AN - SCOPUS:80054122743
SN - 0022-510X
VL - 310
SP - 176
EP - 182
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -