Portal vein thrombosis and survival in patients with cirrhosis

Michael J. Englesbe, James Kubus, Wajee Muhammad, Christopher J. Sonnenday, Theodore Welling, Jeffrey D. Punch, Raymond J. Lynch, Jorge A. Marrero, Shawn J. Pelletier

Research output: Contribution to journalArticle

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Abstract

The effects of occlusive portal vein thrombosis (PVT) on the survival of patients with cirrhosis are unknown. This was a retrospective cohort study at a single center. The main exposure variable was the presence of occlusive PVT. The primary outcome measure was time-dependent mortality. A total of 3295 patients were analyzed, and 148 (4.5%) had PVT. Variables independently predictive of mortality from the time of liver transplant evaluation included age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.01-1.03], Model for End-Stage Liver Disease (MELD) score (HR, 1.10; 95% CI, 1.08-1.11), hepatitis C (HR, 1.44; 95% CI, 1.24-1.68), and PVT (HR, 2.61; 95% CI, 1.97-3.51). Variables independently associated with the risk of mortality from the time of liver transplant listing included age (HR, 1.02; 95% CI, 1.01-1.03), transplantation (HR, 0.65; 95% CI, 0.50-0.81), MELD (HR, 1.08; 95% CI, 1.06-1.10), hepatitis C (HR, 1.50; 95% CI, 1.18-1.90), and PVT (1.99; 95% CI, 1.25-3.16). The presence of occlusive PVT at the time of liver transplantation was associated with an increased risk of death at 30 days (odds ratio, 7.39; 95% CI, 2.39-22.83). In conclusion, patients with cirrhosis complicated by PVT have an increased risk of death.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalLiver Transplantation
Volume16
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Portal Vein
Thrombosis
Fibrosis
Confidence Intervals
Survival
End Stage Liver Disease
Hepatitis C
Mortality
Transplants
Liver
Liver Transplantation
Cohort Studies
Retrospective Studies
Transplantation
Odds Ratio
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Hepatology

Cite this

Englesbe, M. J., Kubus, J., Muhammad, W., Sonnenday, C. J., Welling, T., Punch, J. D., ... Pelletier, S. J. (2010). Portal vein thrombosis and survival in patients with cirrhosis. Liver Transplantation, 16(1), 83-90. https://doi.org/10.1002/lt.21941

Portal vein thrombosis and survival in patients with cirrhosis. / Englesbe, Michael J.; Kubus, James; Muhammad, Wajee; Sonnenday, Christopher J.; Welling, Theodore; Punch, Jeffrey D.; Lynch, Raymond J.; Marrero, Jorge A.; Pelletier, Shawn J.

In: Liver Transplantation, Vol. 16, No. 1, 01.2010, p. 83-90.

Research output: Contribution to journalArticle

Englesbe, MJ, Kubus, J, Muhammad, W, Sonnenday, CJ, Welling, T, Punch, JD, Lynch, RJ, Marrero, JA & Pelletier, SJ 2010, 'Portal vein thrombosis and survival in patients with cirrhosis', Liver Transplantation, vol. 16, no. 1, pp. 83-90. https://doi.org/10.1002/lt.21941
Englesbe MJ, Kubus J, Muhammad W, Sonnenday CJ, Welling T, Punch JD et al. Portal vein thrombosis and survival in patients with cirrhosis. Liver Transplantation. 2010 Jan;16(1):83-90. https://doi.org/10.1002/lt.21941
Englesbe, Michael J. ; Kubus, James ; Muhammad, Wajee ; Sonnenday, Christopher J. ; Welling, Theodore ; Punch, Jeffrey D. ; Lynch, Raymond J. ; Marrero, Jorge A. ; Pelletier, Shawn J. / Portal vein thrombosis and survival in patients with cirrhosis. In: Liver Transplantation. 2010 ; Vol. 16, No. 1. pp. 83-90.
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abstract = "The effects of occlusive portal vein thrombosis (PVT) on the survival of patients with cirrhosis are unknown. This was a retrospective cohort study at a single center. The main exposure variable was the presence of occlusive PVT. The primary outcome measure was time-dependent mortality. A total of 3295 patients were analyzed, and 148 (4.5{\%}) had PVT. Variables independently predictive of mortality from the time of liver transplant evaluation included age [hazard ratio (HR), 1.02; 95{\%} confidence interval (CI), 1.01-1.03], Model for End-Stage Liver Disease (MELD) score (HR, 1.10; 95{\%} CI, 1.08-1.11), hepatitis C (HR, 1.44; 95{\%} CI, 1.24-1.68), and PVT (HR, 2.61; 95{\%} CI, 1.97-3.51). Variables independently associated with the risk of mortality from the time of liver transplant listing included age (HR, 1.02; 95{\%} CI, 1.01-1.03), transplantation (HR, 0.65; 95{\%} CI, 0.50-0.81), MELD (HR, 1.08; 95{\%} CI, 1.06-1.10), hepatitis C (HR, 1.50; 95{\%} CI, 1.18-1.90), and PVT (1.99; 95{\%} CI, 1.25-3.16). The presence of occlusive PVT at the time of liver transplantation was associated with an increased risk of death at 30 days (odds ratio, 7.39; 95{\%} CI, 2.39-22.83). In conclusion, patients with cirrhosis complicated by PVT have an increased risk of death.",
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