Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage

Pawan S. Minhas, David K. Menon, Piotr Smielewski, Marek Czosnyka, Peter J. Kirkpatrick, John C. Clark, John D. Pickard, H. Hunt Batjer, E. Sander Connolly, Issam A. Awad, Arthur L. Day, Philip V. Theodosopoulos

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

OBJECTIVE: After aneurysmal subarachnoid hemorrhage, approximately 30% of patients experience delayed neurological deficits, related in part to arterial vasospasm and dysautoregulation. Transcranial Doppler (TCD) ultrasonography is commonly used to noninvasively detect arterial vasospasm. We studied cerebral perfusion patterns and associated TCD indices for 25 patients who developed clinical signs of delayed neurological deficits. METHODS: Patients were treated in a neurosurgical intensive care unit and were studied if they exhibited delayed focal or global neurological deterioration. Positron emission tomographic cerebral blood flow (CBF) studies and TCD studies measuring the mean flow velocity (FV) of the middle cerebral artery and the middle cerebral artery FV/internal carotid artery FV ratio (with the internal carotid artery FV being measured extracranially at the cranial base) were performed. Glasgow Outcome Scale scores were assessed at 6 months. RESULTS: A markedly heterogeneous pattern of CBF distribution was observed, with hyperemia, normal CBF values, and reduced flow being observed among patients with delayed neurological deficits. TCD indices were not indicative of the cerebral perfusion findings. The mean CBF value was slightly lower for patients who did not survive (32.3 ml/100 g/min), compared with those who did survive (36.0 ml/100 g/min, P = 0.05). CONCLUSION: Among patients who developed delayed neurological deficits after aneurysmal subarachnoid hemorrhage, a wide range of cerebral perfusion disturbances was observed, calling into question the traditional concept of large-vessel vasospasm. Commonly used TCD indices do not reflect cerebral perfusion values.

Original languageEnglish (US)
Pages (from-to)1017-1024
Number of pages8
JournalNeurosurgery
Volume52
Issue number5
StatePublished - May 1 2003

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Cerebrovascular Circulation
Subarachnoid Hemorrhage
Perfusion
Electrons
Middle Cerebral Artery
Internal Carotid Artery
Glasgow Outcome Scale
Doppler Transcranial Ultrasonography
Hyperemia
Skull Base
Intensive Care Units

Keywords

  • Positron emission tomography
  • Subarachnoid hemorrhage
  • Transcranial Doppler ultrasonography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Minhas, P. S., Menon, D. K., Smielewski, P., Czosnyka, M., Kirkpatrick, P. J., Clark, J. C., ... Theodosopoulos, P. V. (2003). Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage. Neurosurgery, 52(5), 1017-1024.

Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage. / Minhas, Pawan S.; Menon, David K.; Smielewski, Piotr; Czosnyka, Marek; Kirkpatrick, Peter J.; Clark, John C.; Pickard, John D.; Batjer, H. Hunt; Connolly, E. Sander; Awad, Issam A.; Day, Arthur L.; Theodosopoulos, Philip V.

In: Neurosurgery, Vol. 52, No. 5, 01.05.2003, p. 1017-1024.

Research output: Contribution to journalArticle

Minhas, PS, Menon, DK, Smielewski, P, Czosnyka, M, Kirkpatrick, PJ, Clark, JC, Pickard, JD, Batjer, HH, Connolly, ES, Awad, IA, Day, AL & Theodosopoulos, PV 2003, 'Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage', Neurosurgery, vol. 52, no. 5, pp. 1017-1024.
Minhas, Pawan S. ; Menon, David K. ; Smielewski, Piotr ; Czosnyka, Marek ; Kirkpatrick, Peter J. ; Clark, John C. ; Pickard, John D. ; Batjer, H. Hunt ; Connolly, E. Sander ; Awad, Issam A. ; Day, Arthur L. ; Theodosopoulos, Philip V. / Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage. In: Neurosurgery. 2003 ; Vol. 52, No. 5. pp. 1017-1024.
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T1 - Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage

AU - Minhas, Pawan S.

AU - Menon, David K.

AU - Smielewski, Piotr

AU - Czosnyka, Marek

AU - Kirkpatrick, Peter J.

AU - Clark, John C.

AU - Pickard, John D.

AU - Batjer, H. Hunt

AU - Connolly, E. Sander

AU - Awad, Issam A.

AU - Day, Arthur L.

AU - Theodosopoulos, Philip V.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - OBJECTIVE: After aneurysmal subarachnoid hemorrhage, approximately 30% of patients experience delayed neurological deficits, related in part to arterial vasospasm and dysautoregulation. Transcranial Doppler (TCD) ultrasonography is commonly used to noninvasively detect arterial vasospasm. We studied cerebral perfusion patterns and associated TCD indices for 25 patients who developed clinical signs of delayed neurological deficits. METHODS: Patients were treated in a neurosurgical intensive care unit and were studied if they exhibited delayed focal or global neurological deterioration. Positron emission tomographic cerebral blood flow (CBF) studies and TCD studies measuring the mean flow velocity (FV) of the middle cerebral artery and the middle cerebral artery FV/internal carotid artery FV ratio (with the internal carotid artery FV being measured extracranially at the cranial base) were performed. Glasgow Outcome Scale scores were assessed at 6 months. RESULTS: A markedly heterogeneous pattern of CBF distribution was observed, with hyperemia, normal CBF values, and reduced flow being observed among patients with delayed neurological deficits. TCD indices were not indicative of the cerebral perfusion findings. The mean CBF value was slightly lower for patients who did not survive (32.3 ml/100 g/min), compared with those who did survive (36.0 ml/100 g/min, P = 0.05). CONCLUSION: Among patients who developed delayed neurological deficits after aneurysmal subarachnoid hemorrhage, a wide range of cerebral perfusion disturbances was observed, calling into question the traditional concept of large-vessel vasospasm. Commonly used TCD indices do not reflect cerebral perfusion values.

AB - OBJECTIVE: After aneurysmal subarachnoid hemorrhage, approximately 30% of patients experience delayed neurological deficits, related in part to arterial vasospasm and dysautoregulation. Transcranial Doppler (TCD) ultrasonography is commonly used to noninvasively detect arterial vasospasm. We studied cerebral perfusion patterns and associated TCD indices for 25 patients who developed clinical signs of delayed neurological deficits. METHODS: Patients were treated in a neurosurgical intensive care unit and were studied if they exhibited delayed focal or global neurological deterioration. Positron emission tomographic cerebral blood flow (CBF) studies and TCD studies measuring the mean flow velocity (FV) of the middle cerebral artery and the middle cerebral artery FV/internal carotid artery FV ratio (with the internal carotid artery FV being measured extracranially at the cranial base) were performed. Glasgow Outcome Scale scores were assessed at 6 months. RESULTS: A markedly heterogeneous pattern of CBF distribution was observed, with hyperemia, normal CBF values, and reduced flow being observed among patients with delayed neurological deficits. TCD indices were not indicative of the cerebral perfusion findings. The mean CBF value was slightly lower for patients who did not survive (32.3 ml/100 g/min), compared with those who did survive (36.0 ml/100 g/min, P = 0.05). CONCLUSION: Among patients who developed delayed neurological deficits after aneurysmal subarachnoid hemorrhage, a wide range of cerebral perfusion disturbances was observed, calling into question the traditional concept of large-vessel vasospasm. Commonly used TCD indices do not reflect cerebral perfusion values.

KW - Positron emission tomography

KW - Subarachnoid hemorrhage

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