Positron emission tomography for measurement of copper fluxes in live organisms

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Copper is an essential nutrient for the physiology of live organisms, but excessive copper can be harmful. Copper radioisotopes are used for measurement of copper fluxes in live organisms using a radioactivity assay of body fluids or whole-body positron emission tomography (PET). Hybrid positron emission tomography-computed tomography (PET/CT) is a versatile tool for real-time measurement of copper fluxes combining the high sensitivity and quantification capability of PET and the superior spatial resolution of CT for anatomic localization of radioactive tracer activity. Kinetic analysis of copper metabolism in the liver and extrahepatic tissues of Atp7b-/- knockout mice, a mouse model of Wilson's disease, demonstrated the feasibility of measuring copper fluxes in live organisms with PET/CT using copper-64 chloride (64CuCl2) as a radioactive tracer (64CuCl2-PET/CT). 64CuCl2-PET/CT holds potential as a useful tool for the diagnosis of inherited and acquired human copper metabolism disorders and for monitoring the effects of copper-modulating therapy.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1314
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Positron emission tomography
Positron-Emission Tomography
Copper
Fluxes
Radioactive Tracers
Copper Radioisotopes
Metabolism
Positron Emission Tomography
Organism
Enzyme kinetics
Hepatolenticular Degeneration
Body fluids
Physiology
Radioactivity
Body Fluids
Time measurement
Knockout Mice
Liver
Nutrients
Tomography

Keywords

  • Copper metabolism
  • Copper-64 chloride
  • Menkes disease
  • PET/CT
  • Positron emission tomography
  • Wilson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Positron emission tomography for measurement of copper fluxes in live organisms. / Peng, Fangyu.

In: Annals of the New York Academy of Sciences, Vol. 1314, No. 1, 2014, p. 24-31.

Research output: Contribution to journalArticle

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