Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene

Lu Q. Le, Janusz H S Kabarowski, Stephane Wong, Khoi Nguyen, Sanjiv S. Gambhir, Owen N. Witte

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

G2A is a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Using HSV-TK reporter gene directed positron emission tomography (PET), we demonstrate that prior to any indication of the onset of illness, mice transplanted with BCR-ABL transduced G2A-deficient bone marrow harbor expanded populations of leukemic cells compared to recipients of wild-type bone marrow. The target cell type and anatomical locations of leukemia development are indistinguishable in animals transplanted with G2A+/+ or G2A-/- cells. Shorter disease latency in the G2A-deficient background is associated with an increased rate of cellular expansion. PET can be successfully applied to the temporal and spatial analysis of Bcr-Abl driven leukemic progression and should have utility for the study of other leukemias and lymphomas.

Original languageEnglish (US)
Pages (from-to)381-391
Number of pages11
JournalCancer Cell
Volume1
Issue number4
DOIs
StatePublished - May 2002

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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