@article{c15666d12f4543cba7dcb13ba1703c29,
title = "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene",
abstract = "G2A is a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Using HSV-TK reporter gene directed positron emission tomography (PET), we demonstrate that prior to any indication of the onset of illness, mice transplanted with BCR-ABL transduced G2A-deficient bone marrow harbor expanded populations of leukemic cells compared to recipients of wild-type bone marrow. The target cell type and anatomical locations of leukemia development are indistinguishable in animals transplanted with G2A+/+ or G2A-/- cells. Shorter disease latency in the G2A-deficient background is associated with an increased rate of cellular expansion. PET can be successfully applied to the temporal and spatial analysis of Bcr-Abl driven leukemic progression and should have utility for the study of other leukemias and lymphomas.",
author = "Le, {Lu Q.} and Kabarowski, {Janusz H S} and Stephane Wong and Khoi Nguyen and Gambhir, {Sanjiv S.} and Witte, {Owen N.}",
note = "Funding Information: We thank Dr. S. Larry Zipursky and members of the Witte lab and Gambhir lab for helpful discussions; James Johnson, Jami McLaughlin, and Shirley Quan for expert technical help; and J.C. White for assistance in the preparation of this manuscript. We are grateful to Dr. Michael Phelps and Dr. Harvey Herschman for introducing us to the benefits of PET reporter gene analysis. L.Q.L. is a Fellow of the University of California, Los Angeles, Medical Scientist Training Program, and supported by a USHHS Institutional National Research Service Award #T32 CA090576 and the Medical Scientist Training Program training grant. J.H.S.K. is a Fellow of the Leukemia and Lymphoma Society (formerly the Leukemia Society of America). O.N.W. is an Investigator of the Howard Hughes Medical Institute. This work was partially supported by NIH grant CA76204 to O.N.W. Imaging described in this paper was supported by funding from DOE contract DE-FC03-87ER60615 (SSG), NIH RO1 CA82214-01 (SSG), and SAIRP R24 CA92865 (SSG).",
year = "2002",
month = may,
doi = "10.1016/S1535-6108(02)00058-2",
language = "English (US)",
volume = "1",
pages = "381--391",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}