Positron emission tomography of the cerebellum in autism

C. W. Chris Heh, R. Smith, J. Wu, E. Hazlett, A. Russell, R. Asarnow, P. Tanguay, M. S. Buchsbaum

Research output: Contribution to journalArticlepeer-review

Abstract

On the basis of neurological evidence that autistic patients have fewer Purkinje and granule cells in the cerebellum as well as vermal cerebellar hypoplasia, the authors tested the hypothesis that autistic patients have cerebellar hypofunctioning. They used positron emission tomography of the cerebellum with 18F-labeled 2-deoxyglucose to study seven autistic patients and eight age-matched control subjects. The results showed no significant difference in mean cerebellar glucose metabolism between the two groups, but all mean glucose rates of the autistic patients were either equal to or greater than those of the control subjects. The implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
JournalAmerican Journal of Psychiatry
Volume146
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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