Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics

Dean F. Wong, Henry N. Wagner, Larry E. Tune, Robert F. Dannals, Godfrey D. Pearlson, Jonathan M. Links, Carol A. Tamminga, Emmanuel P. Broussolle, Hayden T. Ravert, Alan A. Wilson, J. K Thomas Toung, Jan Malat, Jeffery A. Williams, Lorcan A. O'Tuama, Solomon H. Snyder, Michael J. Kuhar, Albert Gjedde

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Abstract

In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic to schizophrenia. With positron emission tomography (PET), the D2 dopamine receptor density in the caudate nucleus of living human beings was measured in normal volunteers and in two groups of patients with schizophrenia-one group that had never been treated with neuroleptics and another group that had been treated with these drugs. D2 dopamine receptor densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers. Thus, schizophrenia itself is associated with an increase in brain D2 dopamine receptor density.

Original languageEnglish (US)
Pages (from-to)1558-1563
Number of pages6
JournalScience
Volume234
Issue number4783
DOIs
StatePublished - Jan 1 1986

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    Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E. P., Ravert, H. T., Wilson, A. A., Toung, J. K. T., Malat, J., Williams, J. A., O'Tuama, L. A., Snyder, S. H., Kuhar, M. J., & Gjedde, A. (1986). Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234(4783), 1558-1563. https://doi.org/10.1126/science.2878495