TY - JOUR
T1 - Possible roles of the pancreatic D-cell in the normal and diabetic states
AU - Unger, Roger H
AU - Orci, L.
PY - 1977
Y1 - 1977
N2 - The A-, D-, and B-cells - the islet cells that contain, respectively, immunoreactive glucagon, somatostatin, and insulin - are distributed within a specialized heterocellular region of the islets of Langerhans as if to permit heterologous contacts between all 3 cell types. Inasmuch as each one of the 3 secretory products of these 3 cell types influences the secretion of at least one of its neighboring cells, 'paracrine' influence on islet hormone secretion becomes a reasonable hypothesis. Glucagon stimulates both insulin and somatostatin release, while insulin and somatostatin both inhibit glucagon release, providing the basis for a feedback relation through which A-cell secretion may be restrained. In addition, glucagon-mediated insulin secretion may be restrained by glucagon-stimulated somatostatin release. Such intercellular relation could help determine the composition of the insulin and glucagon mixtures released within a given metabolic setting.
AB - The A-, D-, and B-cells - the islet cells that contain, respectively, immunoreactive glucagon, somatostatin, and insulin - are distributed within a specialized heterocellular region of the islets of Langerhans as if to permit heterologous contacts between all 3 cell types. Inasmuch as each one of the 3 secretory products of these 3 cell types influences the secretion of at least one of its neighboring cells, 'paracrine' influence on islet hormone secretion becomes a reasonable hypothesis. Glucagon stimulates both insulin and somatostatin release, while insulin and somatostatin both inhibit glucagon release, providing the basis for a feedback relation through which A-cell secretion may be restrained. In addition, glucagon-mediated insulin secretion may be restrained by glucagon-stimulated somatostatin release. Such intercellular relation could help determine the composition of the insulin and glucagon mixtures released within a given metabolic setting.
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U2 - 10.2337/diab.26.3.241
DO - 10.2337/diab.26.3.241
M3 - Article
C2 - 320077
AN - SCOPUS:0017741466
SN - 0012-1797
VL - 26
SP - 241
EP - 244
JO - Diabetes
JF - Diabetes
IS - 3
ER -