Post-modern therapeutic approaches for progressive myoclonus epilepsy

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

While the PME are arguably the severest epilepsies and neurological disorders, the vast majority are monogenic. Additionally, many affect straightforward biochemical pathways. Finally, by definition, they occur in previously healthy and well-developed brains. As such, their therapies should be easier than in complex, albeit often less severe, neurological developmental disorders where the complex, poorly understood, and extremely difficult-to-correct, neural network of the brain is affected. This last article reviews the latest cutting edge technologies in monogenic disease therapy, with some examples provided applicable to a number of disease. It aims to give a sense of where we are and how much closer we are, to the goal of making an actual organic difference.

Original languageEnglish (US)
Pages (from-to)S154-S158
JournalEpileptic Disorders
Volume18
DOIs
StatePublished - 2016

Keywords

  • AAV9
  • CRISPR
  • Cas9
  • gene therapy
  • progressive myoclonus epilepsies
  • small molecule

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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