Post-operative troponin levels and left ventricular function in patients with d-transposition of the great arteries following the arterial switch operation

Sanghee S. Ro, Qinxia Wan, Nikhil Pasumarti, Jenna Keelan, Amee Shah, Ganga Krishnamurthy, Tarif A. Choudhury, Brett R. Anderson, Damien LaPar, Emile Bacha, Michael P. DiLorenzo

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to assess the significance of post-operative troponin levels as a surrogate for left ventricular (LV) dysfunction measured by global longitudinal strain (GLS) in patients with dextro-transposition of the great arteries (d-TGA) who undergo an arterial switch operation (ASO), and to explore the LV GLS recovery in the mid-term follow-up period. Seventy-eight neonates were included, of whom 41 had troponin-I measurements and 37 had troponin-T measurements. The primary outcome of LV GLS was assessed and compared with healthy controls at the pre-operative stage and time of discharge, 3 months, 6 months and 12 months of age. Secondary outcomes included deaths or transplantations and other clinical markers such as length of hospital stay. D-TGA patients had worse LV GLS post-operatively compared to age-matched controls (p < 0.01) which improved by 12 months of age (p = 0.53). No association was found between changes in troponin-I or troponin-T levels and LV GLS at the time of discharge (r = 0.4, p = 0.64 and r = -0.5, p = 0.91, respectively). In addition, there were no deaths or transplantations in this cohort over a period of 12 months. LV GLS appears to worsen in the early post-operative period for d-TGA patients who undergo neonatal ASO but this recovers through the first post-operative year. Troponin levels have limited value in predicting early or midterm LV dysfunction and recovery.

Original languageEnglish (US)
JournalInternational Journal of Cardiovascular Imaging
DOIs
StateAccepted/In press - 2022

Keywords

  • Congenital heart disease
  • Dextro-transposition of the great arteries
  • Longitudinal strain
  • Troponin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Post-operative troponin levels and left ventricular function in patients with d-transposition of the great arteries following the arterial switch operation'. Together they form a unique fingerprint.

Cite this