Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14)

Sadia Sultana, Suhair Al Salihi, Nidhi Tandon, Jesse Jaso, Nghia D. Nguyen, Songlin Zhang, Jing Liu

Research output: Contribution to journalArticle

Abstract

Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. Epstein-Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8- negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalAnnals of Clinical and Laboratory Science
Volume47
Issue number3
Publication statusPublished - May 1 2017

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Keywords

  • Negative HHV8
  • Positive EBV
  • Post-transplant lymphoproliferative disorder (PTLD)
  • Primary effusion lymphoma (PEL)
  • T(8;14)

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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