Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14)

Sadia Sultana, Suhair Al Salihi, Nidhi Tandon, Jesse Jaso, Nghia D. Nguyen, Songlin Zhang, Jing Liu

Research output: Contribution to journalArticle

Abstract

Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. Epstein-Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8- negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalAnnals of Clinical and Laboratory Science
Volume47
Issue number3
StatePublished - May 1 2017

Fingerprint

Primary Effusion Lymphoma
Human Herpesvirus 8
Transplants
Lymphoproliferative Disorders
Viruses
Transplantation (surgical)
Epstein-Barr Virus Infections
Cells
Organ Transplantation
Virus Diseases
Hepatitis B virus
Hepacivirus
Molecular Biology
Acquired Immunodeficiency Syndrome
B-Lymphocytes
Immunohistochemistry
HIV

Keywords

  • Negative HHV8
  • Positive EBV
  • Post-transplant lymphoproliferative disorder (PTLD)
  • Primary effusion lymphoma (PEL)
  • T(8;14)

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14). / Sultana, Sadia; Al Salihi, Suhair; Tandon, Nidhi; Jaso, Jesse; Nguyen, Nghia D.; Zhang, Songlin; Liu, Jing.

In: Annals of Clinical and Laboratory Science, Vol. 47, No. 3, 01.05.2017, p. 344-348.

Research output: Contribution to journalArticle

Sultana, S, Al Salihi, S, Tandon, N, Jaso, J, Nguyen, ND, Zhang, S & Liu, J 2017, 'Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14)', Annals of Clinical and Laboratory Science, vol. 47, no. 3, pp. 344-348.
Sultana, Sadia ; Al Salihi, Suhair ; Tandon, Nidhi ; Jaso, Jesse ; Nguyen, Nghia D. ; Zhang, Songlin ; Liu, Jing. / Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14). In: Annals of Clinical and Laboratory Science. 2017 ; Vol. 47, No. 3. pp. 344-348.
@article{648ceaae2e9040f69f6fe8ffbb88cdc9,
title = "Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14)",
abstract = "Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2{\%} to 10{\%} of transplanted patients. Epstein-Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8- negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.",
keywords = "Negative HHV8, Positive EBV, Post-transplant lymphoproliferative disorder (PTLD), Primary effusion lymphoma (PEL), T(8;14)",
author = "Sadia Sultana and {Al Salihi}, Suhair and Nidhi Tandon and Jesse Jaso and Nguyen, {Nghia D.} and Songlin Zhang and Jing Liu",
year = "2017",
month = "5",
day = "1",
language = "English (US)",
volume = "47",
pages = "344--348",
journal = "Annals of Clinical and Laboratory Science",
issn = "0091-7370",
publisher = "Association of Clinical Scientists",
number = "3",

}

TY - JOUR

T1 - Post-transplant lymphoproliferative disorder presented in a form of primary effusion lymphoma with t (8; 14)

AU - Sultana, Sadia

AU - Al Salihi, Suhair

AU - Tandon, Nidhi

AU - Jaso, Jesse

AU - Nguyen, Nghia D.

AU - Zhang, Songlin

AU - Liu, Jing

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. Epstein-Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8- negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.

AB - Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. Epstein-Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8- negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.

KW - Negative HHV8

KW - Positive EBV

KW - Post-transplant lymphoproliferative disorder (PTLD)

KW - Primary effusion lymphoma (PEL)

KW - T(8;14)

UR - http://www.scopus.com/inward/record.url?scp=85021403796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021403796&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 344

EP - 348

JO - Annals of Clinical and Laboratory Science

JF - Annals of Clinical and Laboratory Science

SN - 0091-7370

IS - 3

ER -