Posterior hippocampal regional cerebral blood flow predicts abstinence: A replication study

Bryon Adinoff, Thomas S. Harris, Hong Gu, Elliot A. Stein

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuous arterial spin labeling magnetic resonance imaging, predicted days to cocaine relapse following residential treatment. In this secondary analysis, we explored whether rCBF in this same pHp region would successfully predict 30-day point prevalence abstinence 60days following residential treatment in an independent group of previously studied participants with cocaine dependence. rCBF was assessed with single photon emission computerized tomography during a saline infusion in 21 cocaine dependence and 22 healthy control participants. pHp rCBF was significantly higher in those endorsing substance use (n=10) relative to both abstinent (n=11) (p

Original languageEnglish (US)
JournalAddiction Biology
DOIs
Publication statusAccepted/In press - 2016

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Keywords

  • Cocaine dependence
  • Hippocampus
  • Limbic system
  • Regional cerebral blood flow
  • Relapse
  • SPECT

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Pharmacology

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