Postoperative changes in resting energy expenditure and interleukin 6 level in infants

M. O. Jones, A. Pierro, I. A. Hashim, A. Shenkin, D. A. Lloyd

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The relationship was determined between resting energy expenditure (REE) and interleukin (IL)6 level following surgery in infants. Sixteen infants of mean(s.e.m.) weight 3.2(0.2) kg undergoing uncomplicated surgery were studied. The operative stress score was recorded and plasma IL-6 levels were measured before and 4, 8, 12 and 24 h after surgery. Respiratory gas exchange was measured by indirect calorimetry before and at 2, 4, 6, 8, 10, 12, 24 and 48 h. Urinary nitrogen excretion was measured and calculated. IL-6 levels increased significantly after surgery (P=0.006) and were maximal at 12 h. There was a linear correlation between the increase in IL-6 level and operative severity score (r=0.61, P=0.012). REE increased significantly after operation (P<0.001), peaking at 2-4 h, and returned to baseline levels by 12 h. The changes in REE preceded those in IL-6. IL-6 is a marker of the stress response in infants and may play a role in the subsequent modulation of this response.

Original languageEnglish (US)
Pages (from-to)536-538
Number of pages3
JournalBritish Journal of Surgery
Volume81
Issue number4
DOIs
StatePublished - 1994

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Energy Metabolism
Interleukin-6
Indirect Calorimetry
Nitrogen
Gases
Weights and Measures

ASJC Scopus subject areas

  • Surgery

Cite this

Postoperative changes in resting energy expenditure and interleukin 6 level in infants. / Jones, M. O.; Pierro, A.; Hashim, I. A.; Shenkin, A.; Lloyd, D. A.

In: British Journal of Surgery, Vol. 81, No. 4, 1994, p. 536-538.

Research output: Contribution to journalArticle

Jones, M. O. ; Pierro, A. ; Hashim, I. A. ; Shenkin, A. ; Lloyd, D. A. / Postoperative changes in resting energy expenditure and interleukin 6 level in infants. In: British Journal of Surgery. 1994 ; Vol. 81, No. 4. pp. 536-538.
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