Postpneumonectomy alveolar growth does not normalize hemodynamic and mechanical function

Shin Ichi Takeda, Murugappan Ramanathan, Aaron S. Estrera, Connie C W Hsia

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Immature foxhounds underwent 55% lung resection by right pneumonectomy (n = 5) or thoracotomy without pneumonectomy (Sham, n = 6) at 2 mo of age. Cardiopulmonary function was measured during treadmill exercise on reaching maturity 1 yr later. In pneumonectomized animals compared with Sham animals, maximal oxygen uptake, ventilatory response, and cardiac output during exercise were normal. Arterial and mixed venous blood gases and arteriovenous oxygen extraction during exercise were also normal. Mean pulmonary arterial pressure and resistance were elevated at a given cardiac output. Dynamic ventilatory power requirement was also significantly elevated at a given minute ventilation. These long-term hemodynamic and mechanical abnormalities are in direct contrast to the normal pulmonary gas exchange during exercise in these same pneumonectomized animals reported elsewhere (S. Takeda, C. C. W. Hsia, E. Wagner, M. Ramanathan, A. S. Estrera, and E. R. Weibel. J. Appl. Physiol. 86: 1301-1310, 1999). Functional compensation was superior in animals pneumonectomized as puppies than as adults. These data indicate a limited structural response of conducting airways and extra-alveolar pulmonary blood vessels to pneumonectomy and suggest the development of other sources of adaptation such as those involving the heart and respiratory muscles.

Original languageEnglish (US)
Pages (from-to)491-497
Number of pages7
JournalJournal of Applied Physiology
Volume87
Issue number2
StatePublished - 1999

Fingerprint

Pneumonectomy
Hemodynamics
Growth
Cardiac Output
Lung
Oxygen
Pulmonary Gas Exchange
Respiratory Muscles
Thoracotomy
Blood Vessels
Ventilation
Myocardium
Arterial Pressure
Gases

Keywords

  • Arteriovenous oxygen extraction
  • Dog
  • Exercise
  • Lung resection
  • Pulmonary arterial pressure
  • Pulmonary arterial resistance
  • Ventilatory power output
  • Work of breathing

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Postpneumonectomy alveolar growth does not normalize hemodynamic and mechanical function. / Takeda, Shin Ichi; Ramanathan, Murugappan; Estrera, Aaron S.; Hsia, Connie C W.

In: Journal of Applied Physiology, Vol. 87, No. 2, 1999, p. 491-497.

Research output: Contribution to journalArticle

Takeda, Shin Ichi ; Ramanathan, Murugappan ; Estrera, Aaron S. ; Hsia, Connie C W. / Postpneumonectomy alveolar growth does not normalize hemodynamic and mechanical function. In: Journal of Applied Physiology. 1999 ; Vol. 87, No. 2. pp. 491-497.
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