Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex

Saïd Kourrich, Stephen D. Glasgow, Douglas A. Caruana, C. Andrew Chapman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. In vitro whole cell recordings have been used here to investigate postsynaptic signalling mechanisms that mediate the induction of long-term synaptic depression (LTD) in layer II entorhinal cortex cells. To induce LTD, pairs of pulses, using a 30-millisecond interval, were delivered at 1Hz for 15minutes. Induction of LTD was blocked by the NMDA receptor antagonist APV and by the calcium chelator BAPTA, consistent with a requirement for calcium influx via NMDA receptors. Induction of LTD was blocked when the FK506 was included in the intracellular solution to block the phosphatase calcineurin. Okadaic acid, which blocks activation of protein phosphatases 1 and 2a, also prevented LTD. Activation of protein phosphatases following calcium influx therefore contributes to induction of LTD in layer II of the entorhinal cortex.

Original languageEnglish (US)
Article number840374
JournalNeural Plasticity
Volume2008
DOIs
StatePublished - 2008

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Long-Term Synaptic Depression
Entorhinal Cortex
N-Methyl-D-Aspartate Receptors
Calcium
Protein Phosphatase 1
Protein Phosphatase 2
Okadaic Acid
Neuronal Plasticity
Phosphoprotein Phosphatases
Tacrolimus
Patch-Clamp Techniques

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology

Cite this

Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex. / Kourrich, Saïd; Glasgow, Stephen D.; Caruana, Douglas A.; Chapman, C. Andrew.

In: Neural Plasticity, Vol. 2008, 840374, 2008.

Research output: Contribution to journalArticle

Kourrich, Saïd ; Glasgow, Stephen D. ; Caruana, Douglas A. ; Chapman, C. Andrew. / Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex. In: Neural Plasticity. 2008 ; Vol. 2008.
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