Postsynaptic supersensitivity in schizophrenia

G. N. Pandey, D. L. Garver, C. Tamminga, S. Ericksen, S. I. Ali, J. M. Davis

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

In the context of the dopamine hypothesis of schizophrenia, the authors examined postsynaptic dopamine (DA) receptor sensitivity in schizophrenic patients by means of a neuroendocrine strategy using the DA receptor agonist apomorphine and growth hormone (GH) release as the measurable postsynaptic event. The activity of platelet adenylate cyclase, an enzyme intimately associated with catecholamine receptor activity, was also studied following stimulation by prostaglandin E 1 (PGE 1). Patients diagnosed as having acute schizophrenia had significantly higher GH responses and adenylate cyclase activity than normal control subjects and patients diagnosed as having chronic schizophrenia. Chronic schizophrenic patients with and without tardive dyskinesia showed GH responses slightly lower than but not significantly different from those of control groups.

Original languageEnglish (US)
Pages (from-to)518-522
Number of pages5
JournalAmerican Journal of Psychiatry
Volume134
Issue number5
StatePublished - 1977

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Schizophrenia
Growth Hormone
Adenylyl Cyclases
Catecholamine Receptors
Apomorphine
Dopamine Agonists
Dopamine Receptors
Prostaglandins E
Dopamine
Blood Platelets
Control Groups
Enzymes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Pandey, G. N., Garver, D. L., Tamminga, C., Ericksen, S., Ali, S. I., & Davis, J. M. (1977). Postsynaptic supersensitivity in schizophrenia. American Journal of Psychiatry, 134(5), 518-522.

Postsynaptic supersensitivity in schizophrenia. / Pandey, G. N.; Garver, D. L.; Tamminga, C.; Ericksen, S.; Ali, S. I.; Davis, J. M.

In: American Journal of Psychiatry, Vol. 134, No. 5, 1977, p. 518-522.

Research output: Contribution to journalArticle

Pandey, GN, Garver, DL, Tamminga, C, Ericksen, S, Ali, SI & Davis, JM 1977, 'Postsynaptic supersensitivity in schizophrenia', American Journal of Psychiatry, vol. 134, no. 5, pp. 518-522.
Pandey GN, Garver DL, Tamminga C, Ericksen S, Ali SI, Davis JM. Postsynaptic supersensitivity in schizophrenia. American Journal of Psychiatry. 1977;134(5):518-522.
Pandey, G. N. ; Garver, D. L. ; Tamminga, C. ; Ericksen, S. ; Ali, S. I. ; Davis, J. M. / Postsynaptic supersensitivity in schizophrenia. In: American Journal of Psychiatry. 1977 ; Vol. 134, No. 5. pp. 518-522.
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