Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Ilya B. Bezprozvanny; Dmitry S. Benevolensky; Alexander P. Naumov

doi:10.1016/0005-2736(91)90413-3

Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Ilya B. Bezprozvanny, Dmitry S. Benevolensky, Alexander P. Naumov

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K⁺ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba²⁺ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	BBA - Biomembranes
Volume	1064
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(91)90413-3
State	Published - Apr 26 1991

Keywords

(Canine aorta)
Barium ion blockage
Bilayer
Conductance level
Microsome
Potassium ion channel
Sarcoplasmic reticulum

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

Access to Document

10.1016/0005-2736(91)90413-3

Fingerprint Dive into the research topics of 'Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states'. Together they form a unique fingerprint.

Cite this

Bezprozvanny, I. B., Benevolensky, D. S., & Naumov, A. P. (1991). Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states. BBA - Biomembranes, 1064(1), 75-80. https://doi.org/10.1016/0005-2736(91)90413-3

@article{c359eaf2a7ce4d34ae04a6d584069fb3,

title = "Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states",

abstract = "The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.",

keywords = "(Canine aorta), Barium ion blockage, Bilayer, Conductance level, Microsome, Potassium ion channel, Sarcoplasmic reticulum",

author = "Bezprozvanny, {Ilya B.} and Benevolensky, {Dmitry S.} and Naumov, {Alexander P.}",

year = "1991",

month = apr,

day = "26",

doi = "10.1016/0005-2736(91)90413-3",

language = "English (US)",

volume = "1064",

pages = "75--80",

journal = "Biochimica et Biophysica Acta - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Potassium channels in aortic microsomes

T2 - conductance, selectivity, barium-induced blockage and subconductance states

AU - Bezprozvanny, Ilya B.

AU - Benevolensky, Dmitry S.

AU - Naumov, Alexander P.

PY - 1991/4/26

Y1 - 1991/4/26

N2 - The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

AB - The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

KW - (Canine aorta)

KW - Barium ion blockage

KW - Bilayer

KW - Conductance level

KW - Microsome

KW - Potassium ion channel

KW - Sarcoplasmic reticulum

UR - http://www.scopus.com/inward/record.url?scp=0025809310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025809310&partnerID=8YFLogxK

U2 - 10.1016/0005-2736(91)90413-3

DO - 10.1016/0005-2736(91)90413-3

M3 - Article

C2 - 2025637

AN - SCOPUS:0025809310

VL - 1064

SP - 75

EP - 80

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

SN - 0005-2736

IS - 1

ER -