Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Ilya B. Bezprozvanny; Dmitry S. Benevolensky; Alexander P. Naumov

doi:10.1016/0005-2736(91)90413-3

Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Ilya B. Bezprozvanny, Dmitry S. Benevolensky, Alexander P. Naumov

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K⁺ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba²⁺ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	BBA - Biomembranes
Volume	1064
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(91)90413-3
State	Published - Apr 26 1991

Keywords

(Canine aorta)
Barium ion blockage
Bilayer
Conductance level
Microsome
Potassium ion channel
Sarcoplasmic reticulum

ASJC Scopus subject areas

Biophysics
Biochemistry
Cell Biology

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10.1016/0005-2736(91)90413-3

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title = "Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states",

abstract = "The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.",

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T1 - Potassium channels in aortic microsomes

T2 - conductance, selectivity, barium-induced blockage and subconductance states

AU - Bezprozvanny, Ilya B.

AU - Benevolensky, Dmitry S.

AU - Naumov, Alexander P.

PY - 1991/4/26

Y1 - 1991/4/26

N2 - The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

AB - The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

KW - (Canine aorta)

KW - Barium ion blockage

KW - Bilayer

KW - Conductance level

KW - Microsome

KW - Potassium ion channel

KW - Sarcoplasmic reticulum

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Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Abstract

Keywords

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