Potassium channels in aortic microsomes: conductance, selectivity, barium-induced blockage and subconductance states

Ilya B. Bezprozvanny, Dmitry S. Benevolensky, Alexander P. Naumov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The activity of potassium channels of canine aortic sarcoplasmic reticulum was measured using the planar lipid bilayer-fusion technique. The channels have a conductance of 208 pS ( 400 100 mM K+ in cis/trans solutions) and potassium-to-sodium permeability ratio of 7.7. Ba2+ ions produced two main effects: one is the interruption of channel currents for tens to hundreds of milliseconds in a voltage-dependent manner, and the other is the appearance of a second conductance level with amplitude about 60% of the main level.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalBBA - Biomembranes
Volume1064
Issue number1
DOIs
StatePublished - Apr 26 1991

Fingerprint

Lipid bilayers
Potassium Channels
Lipid Bilayers
Sarcoplasmic Reticulum
Barium
Microsomes
Canidae
Permeability
Potassium
Fusion reactions
Sodium
Ions
Electric potential

Keywords

  • (Canine aorta)
  • Barium ion blockage
  • Bilayer
  • Conductance level
  • Microsome
  • Potassium ion channel
  • Sarcoplasmic reticulum

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

Cite this

Potassium channels in aortic microsomes : conductance, selectivity, barium-induced blockage and subconductance states. / Bezprozvanny, Ilya B.; Benevolensky, Dmitry S.; Naumov, Alexander P.

In: BBA - Biomembranes, Vol. 1064, No. 1, 26.04.1991, p. 75-80.

Research output: Contribution to journalArticle

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