Potassium: friend or foe?

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The kidney plays an essential role in maintaining homeostasis of ion concentrations in the blood. Because the concentration gradient of potassium across the cell membrane is a key determinant of the membrane potential of cells, even small deviations in serum potassium level from the normal setpoint can lead to severe muscle dysfunction, resulting in respiratory failure and cardiac arrest. Less severe hypo- and hyperkalemia are also associated with morbidity and mortality across various patient populations. In addition, deficiencies in potassium intake have been associated with hypertension and adverse cardiovascular and renal outcomes, likely due in part to the interrelated handling of sodium and potassium by the kidney. Here, data on the beneficial effects of potassium on blood pressure and cardiovascular and renal outcomes will be reviewed, along with the physiological basis for these effects. In some patient populations, however, potassium excess is deleterious. Risk factors for the development of hyperkalemia will be reviewed, as well as the risks and benefits of existing and emerging therapies for hyperkalemia.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalPediatric Nephrology
DOIs
StateAccepted/In press - May 18 2016

Fingerprint

Potassium
Hyperkalemia
Kidney
Potassium Deficiency
Hypokalemia
Heart Arrest
Respiratory Insufficiency
Membrane Potentials
Population
Homeostasis
Sodium
Cell Membrane
Ions
Blood Pressure
Hypertension
Morbidity
Muscles
Mortality
Serum
Therapeutics

Keywords

  • Hyperkalemia
  • Hypokalemia
  • Patiromer
  • Potassium homeostasis
  • Potassium intake
  • Sodium polystyrene sulfonate
  • ZS-9

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Potassium : friend or foe? / Rodan, Aylin R.

In: Pediatric Nephrology, 18.05.2016, p. 1-13.

Research output: Contribution to journalArticle

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