Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia

Norman M Kaplan, A. Carnegie, Philip Raskin, J. A. Heller, M. Simmons

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Abstract

Changes in potassium balance have been found to have variable effects on the blood pressure of animals, and the administration of potassium supplements has been reported to lower the blood pressure of normokalemic hypertensive patients. To assess the effect of potassium repletion in hypokalemic hypertension, we administered either potassium chloride, 60 mmol per day, or placebo tablets, each for six weeks, in a randomized, double-blind, crossover trial to 16 hypertensive patients who had diuretic-induced hypokalemia and who continued to take a constant amount of diuretic. We selected patients whose control serum potassium levels were below 3.5 mmol per liter. In association with an average rise in the serum potassium concentration of 0.56 mmol per liter, the mean blood pressure fell by an average of 5.5 mm Hg (P = 0.004), with at least a 4 mm Hg fall observed in 9 of the 16 patients. The fall in blood pressure correlated with a fall in plasma renin activity (r = 0.568, P = 0.043) but not with changes in plasma aldosterone levels or other variables. We conclude that short-term potassium supplementation that ameliorates diuretic-induced hypokalemia may induce a significant fall in blood pressure.

Original languageEnglish (US)
Pages (from-to)746-749
Number of pages4
JournalNew England Journal of Medicine
Volume312
Issue number12
StatePublished - 1985

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Hypokalemia
Diuretics
Potassium
Blood Pressure
Potassium Chloride
Aldosterone
Serum
Renin
Cross-Over Studies
Tablets
Placebos
Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Potassium supplementation in hypertensive patients with diuretic-induced hypokalemia. / Kaplan, Norman M; Carnegie, A.; Raskin, Philip; Heller, J. A.; Simmons, M.

In: New England Journal of Medicine, Vol. 312, No. 12, 1985, p. 746-749.

Research output: Contribution to journalArticle

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