Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice

Youxue Wang, Kazuhiro Kimura, Ken Ichi Inokuma, Masayuki Saito, Yasuhide Kontani, Yoshinori Kobayashi, Nozomu Mori, Hitoshi Yamashita

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To investigate the thermoregulatory mechanism in mice lacking uncoupling protein 1 (UCP1) from the viewpoint of heat loss, we measured oxygen consumptions (VO2), skin-surface temperatures (Tskin, an index of heat release), blood flows in the tails, and rectal temperatures (Trectal) of mice housed in an animal room under the standard thermal condition of ∼23°C. Compared with wildtype (Ucp1+/+) mice, adult UCP1-deficient (Ucp1 -/-) mice tended to show a reduced VO2. Thermograhic analysis of the acute response of Ucp1-/- mice to a small change (a drop of 1-2°C) in the ambient temperature revealed a sustained fall in the Tskin of Ucp1-/- mice; but this fall was only transient in Ucp1+/+ mice. Analysis of tail blood flow under anesthesia clearly showed a stronger vasoconstrictor response in Ucp1-/- mice than in Ucp1+/+ mice. Administration of a vasodilator, evodiamine, transiently increased Tskin in Ucp1+/+ and Ucp1-/- mice similarly; whereas the induction of vasodilation caused a greater and more prolonged reduction in Trectal in Ucp1-/- mice than in Ucp1+l+ mice. These results indicate that Ucp1-/- mice highly, or at least partly, rely on vasoconstriction for heat conservation to compensate for their UCP1 deficiency and to maintain homeothermy under the condition of normal housing temperature.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalPflugers Archiv European Journal of Physiology
Volume452
Issue number3
DOIs
StatePublished - Jun 2006

Fingerprint

Vasoconstriction
Heat losses
Hot Temperature
Proteins
Blood
Temperature
Vasoconstrictor Agents
Tail
Vasodilator Agents
Conservation
Skin
Animals
Uncoupling Protein 1
Oxygen
Protein Deficiency
Skin Temperature
Vasodilation
Oxygen Consumption
Anesthesia

Keywords

  • Heat release
  • Knockout mouse
  • Thermoregulation
  • Uncoupling protein 1
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology

Cite this

Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. / Wang, Youxue; Kimura, Kazuhiro; Inokuma, Ken Ichi; Saito, Masayuki; Kontani, Yasuhide; Kobayashi, Yoshinori; Mori, Nozomu; Yamashita, Hitoshi.

In: Pflugers Archiv European Journal of Physiology, Vol. 452, No. 3, 06.2006, p. 363-369.

Research output: Contribution to journalArticle

Wang, Youxue ; Kimura, Kazuhiro ; Inokuma, Ken Ichi ; Saito, Masayuki ; Kontani, Yasuhide ; Kobayashi, Yoshinori ; Mori, Nozomu ; Yamashita, Hitoshi. / Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. In: Pflugers Archiv European Journal of Physiology. 2006 ; Vol. 452, No. 3. pp. 363-369.
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