TY - JOUR
T1 - Potential of electron beam computed tomography for coronary artery calcium screening to evaluate fatty liver
T2 - Comparison with 1H magnetic resonance spectroscopy in the Dallas Heart Study
AU - Matulevicius, Susan A
AU - Huff, Laura C.
AU - Szczepaniak, Lidia S.
AU - Ayers, Colby R.
AU - Budoff, Matthew
AU - McColl, Roderick W
AU - Khera, Amit
AU - Peshock, Ronald M
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011/6
Y1 - 2011/6
N2 - Objectives: Electron beam computed tomography (EBCT) for coronary artery calcification can potentially evaluate liver fat, another marker of cardiovascular risk. We compared quantitative estimates of hepatic steatosis measured by EBCT with those obtained by a well-validated, accurate-measure, magnetic resonance spectroscopy (1H MRS). Methods: EBCT and 1H MRS were performed in 2159 subjects from the Dallas Heart Study. Forty subjects were randomly selected from each of 5 subgroups of liver fat percent by 1H MRS (n = 200). EBCT average liver attenuation (HU) was determined in a 1-to 2-cm circular region of interest over the liver lobes. Pearson correlation coefficients were calculated. Using a previously defined 1H MRS hepatic steatosis cut point (>5.5%), an optimized EBCT liver attenuation cut point was determined by receiver operating characteristic analysis. Results: 1H MRS liver fat content and EBCT average right lobe liver attenuation were moderately negatively correlated (r =-0.64, P < 0.0001) in all subjects and in those with 1H MRS hepatic steatosis (r =-0.71, P < 0.0001). This correlation did not improve with attenuation correction of the EBCT data using a standard calcium phantom or statistical transformation. Using an optimized receiver operating characteristic EBCT cut point (64.5 HU), sensitivity was 78% and specificity was 72% for detecting 1H MRS hepatic steatosis, with a high false negative rate. Risk factors for hepatic steatosis (obesity, diabetes mellitus, insulin resistance, metabolic syndrome) were more strongly correlated with 1H MRS than EBCT liver fat measures. Conclusions: Liver attenuation on EBCT acquired for coronary artery calcification screening correlates modestly with 1H MRS measures of liver fat content, with a high false negative rate.
AB - Objectives: Electron beam computed tomography (EBCT) for coronary artery calcification can potentially evaluate liver fat, another marker of cardiovascular risk. We compared quantitative estimates of hepatic steatosis measured by EBCT with those obtained by a well-validated, accurate-measure, magnetic resonance spectroscopy (1H MRS). Methods: EBCT and 1H MRS were performed in 2159 subjects from the Dallas Heart Study. Forty subjects were randomly selected from each of 5 subgroups of liver fat percent by 1H MRS (n = 200). EBCT average liver attenuation (HU) was determined in a 1-to 2-cm circular region of interest over the liver lobes. Pearson correlation coefficients were calculated. Using a previously defined 1H MRS hepatic steatosis cut point (>5.5%), an optimized EBCT liver attenuation cut point was determined by receiver operating characteristic analysis. Results: 1H MRS liver fat content and EBCT average right lobe liver attenuation were moderately negatively correlated (r =-0.64, P < 0.0001) in all subjects and in those with 1H MRS hepatic steatosis (r =-0.71, P < 0.0001). This correlation did not improve with attenuation correction of the EBCT data using a standard calcium phantom or statistical transformation. Using an optimized receiver operating characteristic EBCT cut point (64.5 HU), sensitivity was 78% and specificity was 72% for detecting 1H MRS hepatic steatosis, with a high false negative rate. Risk factors for hepatic steatosis (obesity, diabetes mellitus, insulin resistance, metabolic syndrome) were more strongly correlated with 1H MRS than EBCT liver fat measures. Conclusions: Liver attenuation on EBCT acquired for coronary artery calcification screening correlates modestly with 1H MRS measures of liver fat content, with a high false negative rate.
KW - Electron beam computed tomography
KW - Hepatic steatosis
KW - Magnetic resonance spectroscopy
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U2 - 10.2310/JIM.0b013e318216ad1d
DO - 10.2310/JIM.0b013e318216ad1d
M3 - Article
C2 - 21441828
AN - SCOPUS:85047687992
SN - 1708-8267
VL - 59
SP - 780
EP - 786
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
IS - 5
ER -