Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography

Kiichi Ishiwata, Masaki Mizuno, Yuichi Kimura, Kazunori Kawamura, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kenji Ishii

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5- trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.

Original languageEnglish (US)
Pages (from-to)949-956
Number of pages8
JournalNuclear Medicine and Biology
Volume31
Issue number7
DOIs
StatePublished - Oct 2004

Fingerprint

Adenosine A2A Receptors
Positron-Emission Tomography
Skeletal Muscle
Theophylline
Muscles
Rodentia
Myocardium
KF18446

Keywords

  • [C]TMSX
  • Adenosine A receptor
  • Human
  • Muscle
  • Positron emission tomography

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography. / Ishiwata, Kiichi; Mizuno, Masaki; Kimura, Yuichi; Kawamura, Kazunori; Oda, Keiichi; Sasaki, Toru; Nakamura, Yoshio; Muraoka, Isao; Ishii, Kenji.

In: Nuclear Medicine and Biology, Vol. 31, No. 7, 10.2004, p. 949-956.

Research output: Contribution to journalArticle

Ishiwata, Kiichi ; Mizuno, Masaki ; Kimura, Yuichi ; Kawamura, Kazunori ; Oda, Keiichi ; Sasaki, Toru ; Nakamura, Yoshio ; Muraoka, Isao ; Ishii, Kenji. / Potential of [11C]TMSX for the evaluation of adenosine A 2A receptors in the skeletal muscle by positron emission tomography. In: Nuclear Medicine and Biology. 2004 ; Vol. 31, No. 7. pp. 949-956.
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AU - Oda, Keiichi

AU - Sasaki, Toru

AU - Nakamura, Yoshio

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AU - Ishii, Kenji

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