Potential role of High mobility group box 1 in hepatocellular carcinoma

Rong Rong Zhou, Xu Yuan Kuang, Yan Huang, Ning Li, Ming Xiang Zou, Dao Lin Tang, Xue Gong Fan

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is characterized as a typical inflammation-related carcinoma. High mobility group box protein 1 (HMGB1), a non-histone DNA-binding protein, is identified as a potent proinflammatory mediator when presents extracellularly. Recently, a growing body of evidence indicates that HMGB1 plays a potential role in HCC, but many questions remain unanswered about the relationship between HMGB1 and HCC formation and development. This review focuses on the biological effect of HMGB1, and discusses the association of HMGB1 with HCC and potential use of strategies targeting HMGB1 in HCC treatment.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalCell Adhesion and Migration
Volume8
Issue number5
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

Keywords

  • Biological effect
  • Chronic hepatitis
  • Hepatocellular carcinoma
  • High mobility group box protein 1
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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