Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve

Research output: Contribution to journalReview articlepeer-review

Abstract

In assisted reproductive technology treatment, diminished ovarian reserve (DOR) is a condition of utmost clinical and scientific relevance because of its negative influence on patient outcomes. The current methods of infertility treatment may be unsuitable for many women with DOR, which support the need for development of additional approaches to achieve fertility restoration. Various techniques have been tried to improve the quality and increase the quantity of oocytes in DOR patients, including mitochondrial transfer, activation of primordial follicles, in vitro culture of follicles, and regeneration of oocytes from various stem cells. Herein, we review the science behind these experimental reproductive technologies and their potential use to date in clinical studies for infertility treatment in women with DOR.

Original languageEnglish (US)
Pages (from-to)2507-2517
Number of pages11
JournalJournal of assisted reproduction and genetics
Volume38
Issue number10
DOIs
StatePublished - Oct 2021

Keywords

  • Diminished ovarian reserve
  • Follicle culture
  • Infertility treatment
  • Ovarian tissue cryopreservation
  • Stem cells

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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