Potential therapeutic use of cytokines in gynaecology and obstetrics

Orhan Bukulmez, Aydin Arici

Research output: Contribution to journalArticle

Abstract

Therapeutic manipulation of cytokines may be accomplished by inhibition of a particular cytokine using an antagonist or by administering the cytokine itself. Cytokines appear to have a number of physiological roles, and consequently therapeutic implications, in obstetrics and gynaecology In the central nervous system, interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and increases prolactin levels. Interferon-α and -γ and tumour necrosis factor-α have negative effects on sperm motility and penetration rates. Seminal IL-6 and IL-8 levels correlate negatively with fertility. IL-8 seems to be involved in periovulatory events by attracting and activating neutrophils that play a role in timely follicular rupture. Leukaemia inhibitory factor has been shown to be essential for blastocyst implantation. Interleukin-1 may be one of the signals for the onset of human parturition, and may also play a role in the initiation of preterm labour associated with intra-amniotic infection. In a mouse model, pretreatment with subcutaneous IL-1 receptor antagonist (IL-1ra) prevented IL-1-induced preterm parturition, suggesting a role for the use of anticytokine agents in the treatment of infection associated preterm labour. IL-8 induces cervical ripening when applied locally to the cervix in rabbits, which indicates its pivotal role in cervical maturation. The evaluation of cytokine levels, especially IL-1, may be used as a diagnostic tool to monitor osteoporosis, and drugs such as IL-1ra that interfere with cytokine action could provide new therapies for the effective management of postmenopausal osteoporosis. In spite of all these possibilities, current cytokine-based therapies are still experimental, and numerous problems need to be resolved before they are used in routine clinical applications.

Original languageEnglish (US)
Pages (from-to)193-204
Number of pages12
JournalBioDrugs
Volume8
Issue number3
StatePublished - 1997

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Therapeutic Uses
Gynecology
Obstetrics
Cytokines
Interleukin-1
Interleukin-8
Interleukin-1 Receptors
Premature Obstetric Labor
Parturition
Cervical Ripening
Sperm-Ovum Interactions
Leukemia Inhibitory Factor
Investigational Therapies
Postmenopausal Osteoporosis
Sperm Motility
Therapeutics
Luteinizing Hormone
Infection
Gonadotropin-Releasing Hormone
Cervix Uteri

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Potential therapeutic use of cytokines in gynaecology and obstetrics. / Bukulmez, Orhan; Arici, Aydin.

In: BioDrugs, Vol. 8, No. 3, 1997, p. 193-204.

Research output: Contribution to journalArticle

Bukulmez, Orhan ; Arici, Aydin. / Potential therapeutic use of cytokines in gynaecology and obstetrics. In: BioDrugs. 1997 ; Vol. 8, No. 3. pp. 193-204.
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