Potentially curable pancreatic cancer: American society of clinical oncology clinical practice guideline

Alok A. Khorana, Pamela B. Mangu, Jordan Berlin, Anitra Engebretson, Theodore S. Hong, Anirban Maitra, Supriya G. Mohile, Matthew Mumber, Richard Schulick, Marc Shapiro, Susan Urba, Herbert J. Zeh, Matthew H.G. Katz

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Purpose To provide evidence-based recommendations to oncologists and others on potentially curative therapy for patients with localized pancreatic cancer. Methods ASCO convened a panel of medical oncology, radiation oncology, surgical oncology, palliative care, and advocacy experts and conducted a systematic review of literature from January 2002 to June 2015.Outcomes included overall survival, disease-free survival, progression-free survival, and adverse events. Results Nine randomized controlled trials met the systematic review criteria. Recommendations A multiphase computed tomography scan of the abdomen and pelvis or magnetic resonance imaging should be performed for all patients to assess the anatomic relationships of the primary tumor and for the presence of intra-abdominal metastases. Baseline performance status, comorbidity profile, and goals of care should be evaluated and established. Primary surgical resection is recommended for all patients who have no metastases, appropriate performance and comorbidity profiles, and no radiographic interface between primary tumor and mesenteric vasculature. Preoperative therapy is recommended for patients who meet specific characteristics. All patients with resected pancreatic cancer who did not receive preoperative therapy should be offered 6 months of adjuvant chemotherapy in the absence of contraindications. Adjuvant chemoradiation may be offered to patients who did not receive preoperative therapy with microscopically positive margins (R1) after resection and/or who had node-positive disease after completion of 4 to 6 months of systemic adjuvant chemotherapy. Patients should have a full assessment of symptoms, psychological status, and social supports and should receive palliative care early. Patients who have completed treatment and have no evidence of disease should be monitored.

Original languageEnglish (US)
Pages (from-to)2541-2556
Number of pages16
JournalJournal of Clinical Oncology
Volume34
Issue number21
DOIs
StatePublished - Jul 20 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Khorana, A. A., Mangu, P. B., Berlin, J., Engebretson, A., Hong, T. S., Maitra, A., Mohile, S. G., Mumber, M., Schulick, R., Shapiro, M., Urba, S., Zeh, H. J., & Katz, M. H. G. (2016). Potentially curable pancreatic cancer: American society of clinical oncology clinical practice guideline. Journal of Clinical Oncology, 34(21), 2541-2556. https://doi.org/10.1200/JCO.2016.67.5553