Potentiation of apomorphine and d-amphetamine effects by naloxone

P. M. Adams, R. Beauchamp, C. Alston

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Abstract

The effects of naloxone, an opiate antagonist, on the stereotypic behavior and locomotor activity induced by apomorphine and d-amphetamine were studied. Groups of adult male Sprague-Dawley rats were first tested for stereotypy and locomotor activity after apomorphine (0.0 - 2.0 mg/kg) or d-amphetamine (0.0 - 10.0 mg/kg). Groups were subsequently tested with saline or naloxone (1.0 - 4.0 mg/kg) plus the previously used dosage of apomorphine or d-amphetamine. Naloxone alone did not produce stereotypy, but did significantly reduce locomotor activity. Naloxone potentiated apomorphine and d-amphetamine induced stereotypy. Apomorphine-induced activity was increased by naloxone, but d-amphetamine-induced activity at 2.5 mg/kg was reduced. The results are compatible with the suggestion that naloxone may potentiate both apomorphine and d-amphetamine by inhibiting an opiate receptor mechanism which normally interacts with catecholamine neuronal action.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalLife Sciences
Volume28
Issue number6
DOIs
Publication statusPublished - Feb 9 1981

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ASJC Scopus subject areas

  • Pharmacology

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