Potocytosis

Chieko Mineo, Richard G W Anderson

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Potocytosis represents a mechanism by which small and large molecules as well as macromolecular complexes are sequestered and transported by caveolae. Caveolae are flask-shaped plasma membrane specializations characterized by a filamentous coat consisting of caveolins that decorates the inside surface of each caveola membrane. They have endocytotic functions that differ from the clathrin-coated pit pathway. Ligands bound to receptors that are internalized by caveolae can be delivered to four different locations in the cell bypassing the lysosome and at least four different caveolae membrane traffic patterns during potocytosis can be distinguished. Hence, cells have two endocytic machines and each is designed to accomplish different tasks. This review provides a brief summary of the discovery of caveolae and of potocytosis, and focuses on recent discoveries of the unique endocytic capabilities of caveolae in a variety of different cells.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalHistochemistry and Cell Biology
Volume116
Issue number2
Publication statusPublished - 2001

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Keywords

  • Caveolae
  • Caveolin-1
  • Endocytosis
  • Potocytosis

ASJC Scopus subject areas

  • Cell Biology
  • Instrumentation

Cite this

Mineo, C., & Anderson, R. G. W. (2001). Potocytosis. Histochemistry and Cell Biology, 116(2), 109-118.