Power spectral analyses of systemic arterial pressure and Heart Rate (HR) during central hypovolemia: Effect of age

R. G. Querry, S. A. Smith, R. M. Welch-O'Cornor, I. P. Reese, A. H O Yurvati, P. B. Raven, R. Zhang, X. Shi

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to test the hypothesis that low-frequency (LF) oscillation of systolic arterial pressure (SP) during central hypovolemia was less resposive with aging. Beat to beat SP (intra-arterial catheter or Finapres) and HR in 9 young (Y ≤30yrs) and 7 older (O ≥60yrs) healthy subjects were collected during supine resting, lower body negative pressure (LBNP) -15 & -40 torr for 10 min. A section of 6-min stationary data was selected and resampled at 2 Hz after time binding for the analyses of SP and HR power density (Welch method) and their transfer function gain (calculated using DADiSP software) at high-frequency (HF, 0.15-0.35Hz) and LF (0.04-0.15 Hz). There was no age-related difference in baseline HR or SP. The reflex tachycardia at -40 torr LBNP was significantly greater in Y than O subjects, whereas the SP decrease was similar between the groups. LF power of SP was augmented by LBNP in both groups and this response tended to be greater (P=0.07) in O compared to Y subjects (see table). Group Young Older LBNP torr 0 -15 -40 0 -15 -40 HR bpm 60±3 64±5 76±5*† 55±2 56±2 60±1* SP mmHg 122±4 120±4 113±4* 126±7 116±4* 119±6* HF mmHg2 2.06±0.43 3.28±0.71 1.82±0.24 1.21±0.30 1.29±0.34 2.32±0.58 LF mmHg2 3.41±1.24 3.84±0.85 5.50±1.92* 4.83±0.84 4.62±0.31 9.05±1.37* *indicates a significant change. †denotes a significant difference between the groups. We concluded that a sympathetically mediated vasomotor modulation was not diminished in healthy older subjects during central hypovolemia.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

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hypovolemic shock
Hypovolemia
heart rate
Arterial Pressure
Lower Body Negative Pressure
Heart Rate
Blood Pressure
Healthy Volunteers
Power (Psychology)
Tachycardia
Reflex
Software
Catheters
reflexes
catheters
Transfer functions
oscillation
Aging of materials

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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Power spectral analyses of systemic arterial pressure and Heart Rate (HR) during central hypovolemia : Effect of age. / Querry, R. G.; Smith, S. A.; Welch-O'Cornor, R. M.; Reese, I. P.; Yurvati, A. H O; Raven, P. B.; Zhang, R.; Shi, X.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Querry, R. G. ; Smith, S. A. ; Welch-O'Cornor, R. M. ; Reese, I. P. ; Yurvati, A. H O ; Raven, P. B. ; Zhang, R. ; Shi, X. / Power spectral analyses of systemic arterial pressure and Heart Rate (HR) during central hypovolemia : Effect of age. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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T1 - Power spectral analyses of systemic arterial pressure and Heart Rate (HR) during central hypovolemia

T2 - Effect of age

AU - Querry, R. G.

AU - Smith, S. A.

AU - Welch-O'Cornor, R. M.

AU - Reese, I. P.

AU - Yurvati, A. H O

AU - Raven, P. B.

AU - Zhang, R.

AU - Shi, X.

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Y1 - 1998/3/20

N2 - The purpose of this study was to test the hypothesis that low-frequency (LF) oscillation of systolic arterial pressure (SP) during central hypovolemia was less resposive with aging. Beat to beat SP (intra-arterial catheter or Finapres) and HR in 9 young (Y ≤30yrs) and 7 older (O ≥60yrs) healthy subjects were collected during supine resting, lower body negative pressure (LBNP) -15 & -40 torr for 10 min. A section of 6-min stationary data was selected and resampled at 2 Hz after time binding for the analyses of SP and HR power density (Welch method) and their transfer function gain (calculated using DADiSP software) at high-frequency (HF, 0.15-0.35Hz) and LF (0.04-0.15 Hz). There was no age-related difference in baseline HR or SP. The reflex tachycardia at -40 torr LBNP was significantly greater in Y than O subjects, whereas the SP decrease was similar between the groups. LF power of SP was augmented by LBNP in both groups and this response tended to be greater (P=0.07) in O compared to Y subjects (see table). Group Young Older LBNP torr 0 -15 -40 0 -15 -40 HR bpm 60±3 64±5 76±5*† 55±2 56±2 60±1* SP mmHg 122±4 120±4 113±4* 126±7 116±4* 119±6* HF mmHg2 2.06±0.43 3.28±0.71 1.82±0.24 1.21±0.30 1.29±0.34 2.32±0.58 LF mmHg2 3.41±1.24 3.84±0.85 5.50±1.92* 4.83±0.84 4.62±0.31 9.05±1.37* *indicates a significant change. †denotes a significant difference between the groups. We concluded that a sympathetically mediated vasomotor modulation was not diminished in healthy older subjects during central hypovolemia.

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