PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The vagus nerve innervates visceral organs providing a link between key metabolic cues and the CNS. However, it is not clear whether vagal neurons can directly respond to changing lipid levels and whether altered "lipid sensing" by the vagus nerve regulates energy balance. In this study, we systematically profiled the expression of all known nuclear receptors in laser-captured nodose ganglion (NG) neurons. In particular, we found PPARγ expression was reduced by high-fat-diet feeding. Deletion of PPARγ in Phox2b neurons promoted HFD-induced thermogenesis that involved the reprograming of white adipocyte into a brown-like adipocyte cell fate. Finally, we showed that PPARγ in NG neurons regulates genes necessary for lipid metabolism and those that are important for synaptic transmission. Collectively, our findings provide insights into how vagal afferents survey peripheral metabolic cues and suggest that the reduction of PPARγ in NG neurons may serve as a protective mechanism against diet-induced weight gain.

Original languageEnglish (US)
Pages (from-to)722-730
Number of pages9
JournalCell Metabolism
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2014

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Peroxisome Proliferator-Activated Receptors
Thermogenesis
High Fat Diet
Nodose Ganglion
Neurons
Vagus Nerve
Cues
White Adipocytes
Brown Adipocytes
Lipids
Cytoplasmic and Nuclear Receptors
Lipid Metabolism
Synaptic Transmission
Weight Gain
Lasers
Diet
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology
  • Medicine(all)

Cite this

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis. / Liu, Chen; Bookout, Angie L.; Lee, Syann; Sun, Kai; Jia, Lin; Lee, Charlotte; Udit, Swalpa; Deng, Yingfeng; Scherer, Philipp E.; Mangelsdorf, David J.; Gautron, Laurent; Elmquist, Joel K.

In: Cell Metabolism, Vol. 19, No. 4, 01.04.2014, p. 722-730.

Research output: Contribution to journalArticle

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AU - Udit, Swalpa

AU - Deng, Yingfeng

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